Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry.
(2009) In Journal of Pediatric Hematology/Oncology 31. p.696-701- Abstract
- Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood... (More)
- Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1469324
- author
- Diffner, Eva LU ; Gauffin, Fredrika ; Anagnostaki, Lola ; Nordgren, Ann ; Gustafsson, Bertil ; Sander, Birgitta ; Gustafsson, Britt and Persson, Jenny L LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Pediatric Hematology/Oncology
- volume
- 31
- pages
- 696 - 701
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000269701800018
- pmid:19707156
- scopus:70349113909
- pmid:19707156
- ISSN
- 1536-3678
- DOI
- 10.1097/MPH.0b013e3181b258df
- language
- English
- LU publication?
- yes
- id
- 0b28e023-d1b6-4d50-ae31-da57c2f8d0e9 (old id 1469324)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19707156?dopt=Abstract
- date added to LUP
- 2016-04-04 08:09:31
- date last changed
- 2022-01-29 03:05:16
@article{0b28e023-d1b6-4d50-ae31-da57c2f8d0e9, abstract = {{Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.}}, author = {{Diffner, Eva and Gauffin, Fredrika and Anagnostaki, Lola and Nordgren, Ann and Gustafsson, Bertil and Sander, Birgitta and Gustafsson, Britt and Persson, Jenny L}}, issn = {{1536-3678}}, language = {{eng}}, pages = {{696--701}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Journal of Pediatric Hematology/Oncology}}, title = {{Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry.}}, url = {{http://dx.doi.org/10.1097/MPH.0b013e3181b258df}}, doi = {{10.1097/MPH.0b013e3181b258df}}, volume = {{31}}, year = {{2009}}, }