Complex Relationship Between Blood Pressure and Mortality in Type 2 Diabetic Patients. A Follow-Up of the Botnia Study.
Ronnback, Mats ; Isomaa, Bo ; Fagerudd, Johan ; Forsblom, Carol ; Groop, Per-Henrik ; Tuomi, Tiinamaija LU
and Groop, Leif
LU
(2006)
In Hypertension
47(Dec 27).
p.168-173
- Abstract
- The presence of hypertension aggravates the high cardiovascular risk in type 2 diabetic patients. Pulse pressure is a marker of arterial stiffness and constitutes a risk factor for cardiovascular mortality. This study examines the relationship between different blood pressure indices and mortality in a cohort of type 2 diabetic patients. A total of 1294 type 2 diabetic patients with a median age of 69.1 years participated in the Botnia Study from 1990 to 1997. In 2004, after a median follow-up of 9.5 years, data on mortality was collected from the national population registry and hospital records. Systolic and diastolic blood pressure correlated negatively with mortality after adjustment for other risk factors. The association between low... (More)
- The presence of hypertension aggravates the high cardiovascular risk in type 2 diabetic patients. Pulse pressure is a marker of arterial stiffness and constitutes a risk factor for cardiovascular mortality. This study examines the relationship between different blood pressure indices and mortality in a cohort of type 2 diabetic patients. A total of 1294 type 2 diabetic patients with a median age of 69.1 years participated in the Botnia Study from 1990 to 1997. In 2004, after a median follow-up of 9.5 years, data on mortality was collected from the national population registry and hospital records. Systolic and diastolic blood pressure correlated negatively with mortality after adjustment for other risk factors. The association between low systolic and diastolic blood pressure and mortality was pronounced in patients with previous cardiovascular disease. A U-shaped association between pulse pressure and mortality was observed in elderly patients. These observations could be linked to arterial stiffness and heart failure. Low blood pressure in high-risk patients is likely to be a marker of poor health rather than the cause of mortality. The results suggest that the role of blood pressure as a risk marker in elderly type 2 diabetic patients with cardiovascular disease needs to be reevaluated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/148459
- author
- Ronnback, Mats
; Isomaa, Bo
; Fagerudd, Johan
; Forsblom, Carol
; Groop, Per-Henrik
; Tuomi, Tiinamaija
LU
and Groop, Leif
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diabetes mellitus, cardiovascular diseases, mortality, risk factors, blood pressure, elderly
- in
- Hypertension
- volume
- 47
- issue
- Dec 27
- pages
- 168 - 173
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000234842300011
- scopus:31944435231
- ISSN
- 1524-4563
- DOI
- 10.1161/01.HYP.0000199667.30253.b7
- language
- English
- LU publication?
- yes
- id
- 825d9231-14cd-470d-9573-da75888bda07 (old id 148459)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16380522&dopt=Abstract
- date added to LUP
- 2016-04-01 11:46:08
- date last changed
- 2024-01-07 19:49:44
@article{825d9231-14cd-470d-9573-da75888bda07,
abstract = {{The presence of hypertension aggravates the high cardiovascular risk in type 2 diabetic patients. Pulse pressure is a marker of arterial stiffness and constitutes a risk factor for cardiovascular mortality. This study examines the relationship between different blood pressure indices and mortality in a cohort of type 2 diabetic patients. A total of 1294 type 2 diabetic patients with a median age of 69.1 years participated in the Botnia Study from 1990 to 1997. In 2004, after a median follow-up of 9.5 years, data on mortality was collected from the national population registry and hospital records. Systolic and diastolic blood pressure correlated negatively with mortality after adjustment for other risk factors. The association between low systolic and diastolic blood pressure and mortality was pronounced in patients with previous cardiovascular disease. A U-shaped association between pulse pressure and mortality was observed in elderly patients. These observations could be linked to arterial stiffness and heart failure. Low blood pressure in high-risk patients is likely to be a marker of poor health rather than the cause of mortality. The results suggest that the role of blood pressure as a risk marker in elderly type 2 diabetic patients with cardiovascular disease needs to be reevaluated.}},
author = {{Ronnback, Mats and Isomaa, Bo and Fagerudd, Johan and Forsblom, Carol and Groop, Per-Henrik and Tuomi, Tiinamaija and Groop, Leif}},
issn = {{1524-4563}},
keywords = {{diabetes mellitus; cardiovascular diseases; mortality; risk factors; blood pressure; elderly}},
language = {{eng}},
number = {{Dec 27}},
pages = {{168--173}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Hypertension}},
title = {{Complex Relationship Between Blood Pressure and Mortality in Type 2 Diabetic Patients. A Follow-Up of the Botnia Study.}},
url = {{http://dx.doi.org/10.1161/01.HYP.0000199667.30253.b7}},
doi = {{10.1161/01.HYP.0000199667.30253.b7}},
volume = {{47}},
year = {{2006}},
}