Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery
(2009) In Diabetes, Obesity and Metabolism 11(11). p.1027-1033- Abstract
- Aim Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery. Methods Vertical banded gastroplasty (VBG, n = 7) or jejunoileal bypass (JIB, n = 5) was performed in 12 women, aged 26-39 years, with severe obesity [body mass index (BMI) 46.6 +/- 2.3 kg/m2]. After 1 year, 75 g glucose was administered and plasma levels of glucose, insulin, GIP and GLP-1 were determined regularly during the following 2 h. Results At 1 year after operation, reduction in body weight, actual body weight, fasting glucose or insulin, or the glucose and insulin responses to oral glucose did not differ... (More)
- Aim Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery. Methods Vertical banded gastroplasty (VBG, n = 7) or jejunoileal bypass (JIB, n = 5) was performed in 12 women, aged 26-39 years, with severe obesity [body mass index (BMI) 46.6 +/- 2.3 kg/m2]. After 1 year, 75 g glucose was administered and plasma levels of glucose, insulin, GIP and GLP-1 were determined regularly during the following 2 h. Results At 1 year after operation, reduction in body weight, actual body weight, fasting glucose or insulin, or the glucose and insulin responses to oral glucose did not differ significantly between the groups. Similarly, fasting GIP and GLP-1 levels did not differ significantly between the groups. In contrast, the GIP and GLP-1 responses to oral glucose were different between the groups in a dissociated pattern. Thus, AUC(GIP) was significantly higher after VBG than after JIB (53 +/- 8 vs. 26 +/- 6 pmol/l/min, p = 0.003). In contrast, AUC(GLP-1) was significantly higher after JIB than after VBG (49 +/- 5 vs. 20 +/- 3 pmol/l/min, p = 0.007). Conclusions We conclude that at 1 year after bariatric surgery, the two incretins show dissociated responses in that the GIP secretion is higher after VBG whereas GLP-1 secretion is higher after JIB. This dissociated incretin response is independent from reduction in body weight, glucose tolerance or insulin secretion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1489781
- author
- Guldstrand, M. ; Ahrén, Bo LU ; Naslund, E. ; Holst, J. J. and Adamson, U.
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- glucose tolerance, peptide-1, glucagon-like, GLP-1, glucose-dependent insulinotropic polypeptide, GIP, insulin, obesity, weight reduction
- in
- Diabetes, Obesity and Metabolism
- volume
- 11
- issue
- 11
- pages
- 1027 - 1033
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000270234800005
- scopus:70350192133
- ISSN
- 1462-8902
- DOI
- 10.1111/j.1463-1326.2009.01089.x
- language
- English
- LU publication?
- yes
- id
- 0bede272-42fc-4849-bd7a-b2e568fa82c0 (old id 1489781)
- date added to LUP
- 2016-04-01 12:13:21
- date last changed
- 2024-01-08 12:42:50
@article{0bede272-42fc-4849-bd7a-b2e568fa82c0,
abstract = {{Aim Compare the response to oral glucose of the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) at 1 year after restrictive vs. malabsorptive bariatric surgery. Methods Vertical banded gastroplasty (VBG, n = 7) or jejunoileal bypass (JIB, n = 5) was performed in 12 women, aged 26-39 years, with severe obesity [body mass index (BMI) 46.6 +/- 2.3 kg/m2]. After 1 year, 75 g glucose was administered and plasma levels of glucose, insulin, GIP and GLP-1 were determined regularly during the following 2 h. Results At 1 year after operation, reduction in body weight, actual body weight, fasting glucose or insulin, or the glucose and insulin responses to oral glucose did not differ significantly between the groups. Similarly, fasting GIP and GLP-1 levels did not differ significantly between the groups. In contrast, the GIP and GLP-1 responses to oral glucose were different between the groups in a dissociated pattern. Thus, AUC(GIP) was significantly higher after VBG than after JIB (53 +/- 8 vs. 26 +/- 6 pmol/l/min, p = 0.003). In contrast, AUC(GLP-1) was significantly higher after JIB than after VBG (49 +/- 5 vs. 20 +/- 3 pmol/l/min, p = 0.007). Conclusions We conclude that at 1 year after bariatric surgery, the two incretins show dissociated responses in that the GIP secretion is higher after VBG whereas GLP-1 secretion is higher after JIB. This dissociated incretin response is independent from reduction in body weight, glucose tolerance or insulin secretion.}},
author = {{Guldstrand, M. and Ahrén, Bo and Naslund, E. and Holst, J. J. and Adamson, U.}},
issn = {{1462-8902}},
keywords = {{glucose tolerance; peptide-1; glucagon-like; GLP-1; glucose-dependent insulinotropic polypeptide; GIP; insulin; obesity; weight reduction}},
language = {{eng}},
number = {{11}},
pages = {{1027--1033}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetes, Obesity and Metabolism}},
title = {{Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery}},
url = {{http://dx.doi.org/10.1111/j.1463-1326.2009.01089.x}},
doi = {{10.1111/j.1463-1326.2009.01089.x}},
volume = {{11}},
year = {{2009}},
}