SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis
(2005) In Journal of Natural Products 68(8). p.1213-1217- Abstract
- An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/152347
- author
- Appendino, G ; Prosperini, S ; Valdivia, Carola LU ; Ballero, M ; Colombano, G ; Billington, R A ; Genazzani, A A and Sterner, Olov LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Natural Products
- volume
- 68
- issue
- 8
- pages
- 1213 - 1217
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:16124763
- wos:000231578000014
- scopus:24744471405
- ISSN
- 0163-3864
- DOI
- 10.1021/np050115m
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 6ae10736-4a0d-44fa-926b-2eac5489e690 (old id 152347)
- date added to LUP
- 2016-04-01 16:40:56
- date last changed
- 2022-03-22 20:25:22
@article{6ae10736-4a0d-44fa-926b-2eac5489e690, abstract = {{An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.}}, author = {{Appendino, G and Prosperini, S and Valdivia, Carola and Ballero, M and Colombano, G and Billington, R A and Genazzani, A A and Sterner, Olov}}, issn = {{0163-3864}}, language = {{eng}}, number = {{8}}, pages = {{1213--1217}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of Natural Products}}, title = {{SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis}}, url = {{http://dx.doi.org/10.1021/np050115m}}, doi = {{10.1021/np050115m}}, volume = {{68}}, year = {{2005}}, }