No association of the IRS1 and PAX4 genes with type I diabetes
(2009) In Genes and Immunity 10. p.49-53- Abstract
- To reassess earlier suggested type I diabetes (T1D) associations of the insulin receptor substrate 1 (IRS1) and the paired domain 4 gene (PAX4) genes, the Type I Diabetes Genetics Consortium (T1DGC) evaluated single-nucleotide polymorphisms (SNPs) covering the two genomic regions. Sixteen SNPs were evaluated for IRS1 and 10 for PAX4. Both genes are biological candidate genes for T1D. Genotyping was performed in 2300 T1D families on both Illumina and Sequenom genotyping platforms. Data quality and concordance between the platforms were assessed for each SNP. Transmission disequilibrium testing neither show T1D association of SNPs in the two genes, nor did haplotype analysis. In conclusion, the earlier suggested associations of IRS1 and PAX4... (More)
- To reassess earlier suggested type I diabetes (T1D) associations of the insulin receptor substrate 1 (IRS1) and the paired domain 4 gene (PAX4) genes, the Type I Diabetes Genetics Consortium (T1DGC) evaluated single-nucleotide polymorphisms (SNPs) covering the two genomic regions. Sixteen SNPs were evaluated for IRS1 and 10 for PAX4. Both genes are biological candidate genes for T1D. Genotyping was performed in 2300 T1D families on both Illumina and Sequenom genotyping platforms. Data quality and concordance between the platforms were assessed for each SNP. Transmission disequilibrium testing neither show T1D association of SNPs in the two genes, nor did haplotype analysis. In conclusion, the earlier suggested associations of IRS1 and PAX4 to T1D were not supported, suggesting that they may have been false positive results. This highlights the importance of thorough quality control, selection of tagging SNPs, more than one genotyping platform in high throughput studies, and sufficient power to draw solid conclusions in genetic studies of human complex diseases. Genes and Immunity (2009) 10, S49-S53; doi:10.1038/gene.2009.91 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1533518
- author
- Bergholdt, R. ; Brorsson, Caroline LU ; Boehm, B. ; Morahan, G. and Pociot, Flemming
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- type I diabetes, IRS1, PAX4, polymorphism, single-nucleotide, autoimmune disease, genetic susceptibility
- in
- Genes and Immunity
- volume
- 10
- pages
- 49 - 53
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000272419900008
- scopus:75649149543
- ISSN
- 1476-5470
- DOI
- 10.1038/gene.2009.91
- language
- English
- LU publication?
- yes
- id
- 2aa44f84-c4ad-4f57-a713-ef4e13244a5b (old id 1533518)
- date added to LUP
- 2016-04-01 12:28:00
- date last changed
- 2024-01-08 21:28:54
@article{2aa44f84-c4ad-4f57-a713-ef4e13244a5b, abstract = {{To reassess earlier suggested type I diabetes (T1D) associations of the insulin receptor substrate 1 (IRS1) and the paired domain 4 gene (PAX4) genes, the Type I Diabetes Genetics Consortium (T1DGC) evaluated single-nucleotide polymorphisms (SNPs) covering the two genomic regions. Sixteen SNPs were evaluated for IRS1 and 10 for PAX4. Both genes are biological candidate genes for T1D. Genotyping was performed in 2300 T1D families on both Illumina and Sequenom genotyping platforms. Data quality and concordance between the platforms were assessed for each SNP. Transmission disequilibrium testing neither show T1D association of SNPs in the two genes, nor did haplotype analysis. In conclusion, the earlier suggested associations of IRS1 and PAX4 to T1D were not supported, suggesting that they may have been false positive results. This highlights the importance of thorough quality control, selection of tagging SNPs, more than one genotyping platform in high throughput studies, and sufficient power to draw solid conclusions in genetic studies of human complex diseases. Genes and Immunity (2009) 10, S49-S53; doi:10.1038/gene.2009.91}}, author = {{Bergholdt, R. and Brorsson, Caroline and Boehm, B. and Morahan, G. and Pociot, Flemming}}, issn = {{1476-5470}}, keywords = {{type I diabetes; IRS1; PAX4; polymorphism; single-nucleotide; autoimmune disease; genetic susceptibility}}, language = {{eng}}, pages = {{49--53}}, publisher = {{Nature Publishing Group}}, series = {{Genes and Immunity}}, title = {{No association of the IRS1 and PAX4 genes with type I diabetes}}, url = {{http://dx.doi.org/10.1038/gene.2009.91}}, doi = {{10.1038/gene.2009.91}}, volume = {{10}}, year = {{2009}}, }