Haemophilus influenzae and the complement system.
Hallström, Teresia LU and Riesbeck, Kristian LU
(2010)
In Trends in Microbiology
Mar 4.
p.258-265
- Abstract
- The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for... (More)
- The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for understanding pathogenesis and for developing vaccines and new therapies aimed at patients with, for example, chronic obstructive pulmonary disease. Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1595138
- author
- Hallström, Teresia
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Microbiology
- volume
- Mar 4
- pages
- 258 - 265
- publisher
- Elsevier
- external identifiers
-
- wos:000279090000005
- pmid:20399102
- scopus:78049490091
- pmid:20399102
- ISSN
- 1878-4380
- DOI
- 10.1016/j.tim.2010.03.007
- language
- English
- LU publication?
- yes
- id
- 028a344b-e927-4f05-b242-c403ae0802e7 (old id 1595138)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20399102?dopt=Abstract
- date added to LUP
- 2016-04-04 09:13:21
- date last changed
- 2022-03-15 18:15:22
@article{028a344b-e927-4f05-b242-c403ae0802e7,
abstract = {{The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for understanding pathogenesis and for developing vaccines and new therapies aimed at patients with, for example, chronic obstructive pulmonary disease. Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system.}},
author = {{Hallström, Teresia and Riesbeck, Kristian}},
issn = {{1878-4380}},
language = {{eng}},
pages = {{258--265}},
publisher = {{Elsevier}},
series = {{Trends in Microbiology}},
title = {{Haemophilus influenzae and the complement system.}},
url = {{https://lup.lub.lu.se/search/files/5264874/1639436.pdf}},
doi = {{10.1016/j.tim.2010.03.007}},
volume = {{Mar 4}},
year = {{2010}},
}