Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis
(2019) In Phlebology 34(3). p.171-178- Abstract
Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding... (More)
Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.
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- author
- Salim, Saman LU ; Ekberg, Olle LU ; Elf, Johan LU ; Zarrouk, Moncef LU ; Gottsäter, Anders LU and Acosta, Stefan LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anticoagulation, computed tomography, direct oral anticoagulants, efficacy, Mesenteric venous thrombosis, recanalization, safety
- in
- Phlebology
- volume
- 34
- issue
- 3
- pages
- 171 - 178
- publisher
- Springer
- external identifiers
-
- pmid:29848218
- scopus:85047928818
- ISSN
- 0268-3555
- DOI
- 10.1177/0268355518779517
- language
- English
- LU publication?
- yes
- id
- 15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0
- date added to LUP
- 2018-06-14 16:08:46
- date last changed
- 2024-09-17 22:25:22
@article{15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0, abstract = {{<p>Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.</p>}}, author = {{Salim, Saman and Ekberg, Olle and Elf, Johan and Zarrouk, Moncef and Gottsäter, Anders and Acosta, Stefan}}, issn = {{0268-3555}}, keywords = {{anticoagulation; computed tomography; direct oral anticoagulants; efficacy; Mesenteric venous thrombosis; recanalization; safety}}, language = {{eng}}, number = {{3}}, pages = {{171--178}}, publisher = {{Springer}}, series = {{Phlebology}}, title = {{Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis}}, url = {{http://dx.doi.org/10.1177/0268355518779517}}, doi = {{10.1177/0268355518779517}}, volume = {{34}}, year = {{2019}}, }