Repeatability of T1-quantification in dGEMRIC for three different acquisition techniques: two-dimensional inversion recovery, three-dimensional look locker, and three-dimensional variable flip angle.
(2010) In Journal of Magnetic Resonance Imaging 31(5). p.1203-1209- Abstract
- PURPOSE: To evaluate the repeatability of the dGEMRIC (delayed gadolinium enhanced MRI of cartilage) method in osteoarthritis-prone knee joints for three different T1 quantification techniques: two-dimensional inversion recovery (2D-IR), three-dimensional Look-Locker (3D-LL), and three-dimensional variable flip angle (3D-VFA). MATERIALS AND METHODS: Nine subjects were examined twice, with a 2-week interval, using all three measurement techniques. Four regions of interest were defined in the central medial and lateral femoral cartilage. The repeatability was evaluated for each measurement technique. For the 3D techniques, the variation between different slices was also evaluated. RESULTS: Repeatability expressed by root-mean-square... (More)
- PURPOSE: To evaluate the repeatability of the dGEMRIC (delayed gadolinium enhanced MRI of cartilage) method in osteoarthritis-prone knee joints for three different T1 quantification techniques: two-dimensional inversion recovery (2D-IR), three-dimensional Look-Locker (3D-LL), and three-dimensional variable flip angle (3D-VFA). MATERIALS AND METHODS: Nine subjects were examined twice, with a 2-week interval, using all three measurement techniques. Four regions of interest were defined in the central medial and lateral femoral cartilage. The repeatability was evaluated for each measurement technique. For the 3D techniques, the variation between different slices was also evaluated. RESULTS: Repeatability expressed by root-mean-square coefficient of variation (CV(RMS)) showed similar results for 2D-IR and 3D-LL (5.4-8.4%). For 3D-VFA CV(RMS) was higher (9.3-15.2%). Intraclass correlation coefficient showed both 2D-IR and 3D-LL reliability to be moderate, while 3D-VFA reliability was low. Inter-slice CV(RMS) and ICC was of the same magnitude as the repeatability. No clear differences could be interpreted between the condyles. CONCLUSION: Both 2D-IR and 3D-LL perform well in generating repeatable dGEMRIC results, while 3D-VFA results are somewhat inferior. Furthermore, repeatability results in this study are similar to previously published results for healthy subjects. Finally, the positioning of the analyzed images is crucial to generate reliable repeatability results. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1610692
- author
- Siversson, Carl LU ; Tiderius, Carl Johan LU ; Neuman, Paul LU ; Dahlberg, Leif LU and Svensson, Jonas LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Magnetic Resonance Imaging
- volume
- 31
- issue
- 5
- pages
- 1203 - 1209
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000277397100021
- pmid:20432357
- scopus:77951573905
- pmid:20432357
- ISSN
- 1522-2586
- DOI
- 10.1002/jmri.22159
- language
- English
- LU publication?
- yes
- id
- 689b2116-0da0-4dbe-a380-c8036cb9a2e2 (old id 1610692)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20432357?dopt=Abstract
- date added to LUP
- 2016-04-04 08:20:58
- date last changed
- 2022-01-29 03:21:22
@article{689b2116-0da0-4dbe-a380-c8036cb9a2e2,
abstract = {{PURPOSE: To evaluate the repeatability of the dGEMRIC (delayed gadolinium enhanced MRI of cartilage) method in osteoarthritis-prone knee joints for three different T1 quantification techniques: two-dimensional inversion recovery (2D-IR), three-dimensional Look-Locker (3D-LL), and three-dimensional variable flip angle (3D-VFA). MATERIALS AND METHODS: Nine subjects were examined twice, with a 2-week interval, using all three measurement techniques. Four regions of interest were defined in the central medial and lateral femoral cartilage. The repeatability was evaluated for each measurement technique. For the 3D techniques, the variation between different slices was also evaluated. RESULTS: Repeatability expressed by root-mean-square coefficient of variation (CV(RMS)) showed similar results for 2D-IR and 3D-LL (5.4-8.4%). For 3D-VFA CV(RMS) was higher (9.3-15.2%). Intraclass correlation coefficient showed both 2D-IR and 3D-LL reliability to be moderate, while 3D-VFA reliability was low. Inter-slice CV(RMS) and ICC was of the same magnitude as the repeatability. No clear differences could be interpreted between the condyles. CONCLUSION: Both 2D-IR and 3D-LL perform well in generating repeatable dGEMRIC results, while 3D-VFA results are somewhat inferior. Furthermore, repeatability results in this study are similar to previously published results for healthy subjects. Finally, the positioning of the analyzed images is crucial to generate reliable repeatability results.}},
author = {{Siversson, Carl and Tiderius, Carl Johan and Neuman, Paul and Dahlberg, Leif and Svensson, Jonas}},
issn = {{1522-2586}},
language = {{eng}},
number = {{5}},
pages = {{1203--1209}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Magnetic Resonance Imaging}},
title = {{Repeatability of T1-quantification in dGEMRIC for three different acquisition techniques: two-dimensional inversion recovery, three-dimensional look locker, and three-dimensional variable flip angle.}},
url = {{http://dx.doi.org/10.1002/jmri.22159}},
doi = {{10.1002/jmri.22159}},
volume = {{31}},
year = {{2010}},
}