CGRP receptor antagonism and migraine.
(2010) In Neurotherapeutics 7(2). p.164-175- Abstract
- Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric nervous system. In the CNS there is a wide distribution of CGRP-containing neurons, with the highest levels occurring in striatum, amygdala, colliculi, and cerebellum. The peripheral projections are involved in neurogenic vasodilatation and inflammation, and central release induces hyperalgesia. CGRP is released from trigeminal nerves in migraine. Trigeminal nerve activation results in... (More)
- Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric nervous system. In the CNS there is a wide distribution of CGRP-containing neurons, with the highest levels occurring in striatum, amygdala, colliculi, and cerebellum. The peripheral projections are involved in neurogenic vasodilatation and inflammation, and central release induces hyperalgesia. CGRP is released from trigeminal nerves in migraine. Trigeminal nerve activation results in antidromic release of CGRP to cause non-endothelium-mediated vasodilatation. At the central synapses in the trigeminal nucleus caudalis, CGRP acts postjunctionally on second-order neurons to transmit pain signals centrally via the brainstem and midbrain to the thalamus and higher cortical pain regions. Recently developed CGRP receptor antagonists are effective at aborting acute migraine attacks. They may act both centrally and peripherally to attenuate signaling within the trigeminovascular pathway. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1610722
- author
- Edvinsson, Lars LU and Ho, Tony W
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurotherapeutics
- volume
- 7
- issue
- 2
- pages
- 164 - 175
- publisher
- Springer
- external identifiers
-
- wos:000277082300004
- pmid:20430315
- scopus:77953264523
- ISSN
- 1878-7479
- DOI
- 10.1016/j.nurt.2010.02.004
- language
- English
- LU publication?
- yes
- id
- 58b4026a-e29b-4819-86c4-f864a0cbbf62 (old id 1610722)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20430315?dopt=Abstract
- date added to LUP
- 2016-04-04 07:37:52
- date last changed
- 2024-01-12 02:02:20
@article{58b4026a-e29b-4819-86c4-f864a0cbbf62,
abstract = {{Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric nervous system. In the CNS there is a wide distribution of CGRP-containing neurons, with the highest levels occurring in striatum, amygdala, colliculi, and cerebellum. The peripheral projections are involved in neurogenic vasodilatation and inflammation, and central release induces hyperalgesia. CGRP is released from trigeminal nerves in migraine. Trigeminal nerve activation results in antidromic release of CGRP to cause non-endothelium-mediated vasodilatation. At the central synapses in the trigeminal nucleus caudalis, CGRP acts postjunctionally on second-order neurons to transmit pain signals centrally via the brainstem and midbrain to the thalamus and higher cortical pain regions. Recently developed CGRP receptor antagonists are effective at aborting acute migraine attacks. They may act both centrally and peripherally to attenuate signaling within the trigeminovascular pathway.}},
author = {{Edvinsson, Lars and Ho, Tony W}},
issn = {{1878-7479}},
language = {{eng}},
number = {{2}},
pages = {{164--175}},
publisher = {{Springer}},
series = {{Neurotherapeutics}},
title = {{CGRP receptor antagonism and migraine.}},
url = {{http://dx.doi.org/10.1016/j.nurt.2010.02.004}},
doi = {{10.1016/j.nurt.2010.02.004}},
volume = {{7}},
year = {{2010}},
}