Non-contact acoustic cell trapping in disposable glass capillaries.
(2010) In Lab on a Chip 10. p.2251-2257- Abstract
- Non-contact trapping using acoustic standing waves has shown promising results in cell-based research lately. However, the devices demonstrated are normally fabricated using microfabrication or precision machining methods leading to a high unit cost. In e.g. clinical or forensic applications avoiding cross-contamination, carryover or infection is of outmost importance. In these applications disposable devices are key elements, thus making the cost per unit a critical factor. A solution is presented here where low-cost off-the-shelf glass capillaries are used as resonators for standing wave trapping. Single-mode as well as multi-node trapping is demonstrated with an excellent agreement between simulated and experimentally found operation... (More)
- Non-contact trapping using acoustic standing waves has shown promising results in cell-based research lately. However, the devices demonstrated are normally fabricated using microfabrication or precision machining methods leading to a high unit cost. In e.g. clinical or forensic applications avoiding cross-contamination, carryover or infection is of outmost importance. In these applications disposable devices are key elements, thus making the cost per unit a critical factor. A solution is presented here where low-cost off-the-shelf glass capillaries are used as resonators for standing wave trapping. Single-mode as well as multi-node trapping is demonstrated with an excellent agreement between simulated and experimentally found operation frequencies. Single particle trapping is verified at 7.53 MHz with a trapping force on a 10 mum particle of up to 1.27 nN. The non-contact trapping is proved using confocal microscopy. Finally, an application is presented where the capillary is used as a pipette for aspirating, trapping and dispensing red blood cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1645462
- author
- Hammarström, Björn LU ; Evander, Mikael LU ; Barbeau, Herve ; Bruzelius, Mattias ; Larsson, Jörgen ; Laurell, Thomas LU and Nilsson, Johan LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Lab on a Chip
- volume
- 10
- pages
- 2251 - 2257
- publisher
- Royal Society of Chemistry
- external identifiers
-
- pmid:20589284
- wos:000280812600011
- scopus:77955537975
- pmid:20589284
- ISSN
- 1473-0189
- DOI
- 10.1039/c004504g
- language
- English
- LU publication?
- yes
- id
- 9289d1a4-48ad-4f92-92cc-97902d4ad137 (old id 1645462)
- date added to LUP
- 2016-04-01 10:10:17
- date last changed
- 2022-04-12 02:39:32
@article{9289d1a4-48ad-4f92-92cc-97902d4ad137,
abstract = {{Non-contact trapping using acoustic standing waves has shown promising results in cell-based research lately. However, the devices demonstrated are normally fabricated using microfabrication or precision machining methods leading to a high unit cost. In e.g. clinical or forensic applications avoiding cross-contamination, carryover or infection is of outmost importance. In these applications disposable devices are key elements, thus making the cost per unit a critical factor. A solution is presented here where low-cost off-the-shelf glass capillaries are used as resonators for standing wave trapping. Single-mode as well as multi-node trapping is demonstrated with an excellent agreement between simulated and experimentally found operation frequencies. Single particle trapping is verified at 7.53 MHz with a trapping force on a 10 mum particle of up to 1.27 nN. The non-contact trapping is proved using confocal microscopy. Finally, an application is presented where the capillary is used as a pipette for aspirating, trapping and dispensing red blood cells.}},
author = {{Hammarström, Björn and Evander, Mikael and Barbeau, Herve and Bruzelius, Mattias and Larsson, Jörgen and Laurell, Thomas and Nilsson, Johan}},
issn = {{1473-0189}},
language = {{eng}},
pages = {{2251--2257}},
publisher = {{Royal Society of Chemistry}},
series = {{Lab on a Chip}},
title = {{Non-contact acoustic cell trapping in disposable glass capillaries.}},
url = {{http://dx.doi.org/10.1039/c004504g}},
doi = {{10.1039/c004504g}},
volume = {{10}},
year = {{2010}},
}