Gene expression regulation and lineage evolution: the North and South tale of the hybrid polyploid Squalius alburnoides complex
(2010) In Royal Society of London. Proceedings B. Biological Sciences 277(1699). p.3519-3525- Abstract
- The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the... (More)
- The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the distribution range of the complex. Here we show that the allele-specific patterns of silencing vary within the complex, according to the geographical origin and the type of genome involved in the hybridization process. In southern populations, triploids of S. alburnoides show an overall tendency for silencing the allele from the minority genome, while northern population polyploids exhibit preferential biallelic gene expression patterns, irrespective of genomic composition. The present findings further suggest that gene copy silencing and variable expression of specific allele combinations may be important processes in vertebrate polyploid evolution. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1720232
- author
- Pala, Irene LU ; Schartl, Manfred ; Brito, Miguel ; Vacas, Joana Malta and Coelho, Maria Manuela
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hybrid lineage, allele silencing, allopolyploid, gene expression, evolution
- in
- Royal Society of London. Proceedings B. Biological Sciences
- volume
- 277
- issue
- 1699
- pages
- 3519 - 3525
- publisher
- Royal Society Publishing
- external identifiers
-
- wos:000283448800018
- scopus:78149245728
- pmid:20554543
- ISSN
- 1471-2954
- DOI
- 10.1098/rspb.2010.1071
- language
- English
- LU publication?
- yes
- id
- b43558c1-58b0-473f-9df3-edce2a57ba68 (old id 1720232)
- date added to LUP
- 2016-04-01 14:02:34
- date last changed
- 2022-01-27 22:33:29
@article{b43558c1-58b0-473f-9df3-edce2a57ba68,
abstract = {{The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the distribution range of the complex. Here we show that the allele-specific patterns of silencing vary within the complex, according to the geographical origin and the type of genome involved in the hybridization process. In southern populations, triploids of S. alburnoides show an overall tendency for silencing the allele from the minority genome, while northern population polyploids exhibit preferential biallelic gene expression patterns, irrespective of genomic composition. The present findings further suggest that gene copy silencing and variable expression of specific allele combinations may be important processes in vertebrate polyploid evolution.}},
author = {{Pala, Irene and Schartl, Manfred and Brito, Miguel and Vacas, Joana Malta and Coelho, Maria Manuela}},
issn = {{1471-2954}},
keywords = {{hybrid lineage; allele silencing; allopolyploid; gene expression; evolution}},
language = {{eng}},
number = {{1699}},
pages = {{3519--3525}},
publisher = {{Royal Society Publishing}},
series = {{Royal Society of London. Proceedings B. Biological Sciences}},
title = {{Gene expression regulation and lineage evolution: the North and South tale of the hybrid polyploid Squalius alburnoides complex}},
url = {{http://dx.doi.org/10.1098/rspb.2010.1071}},
doi = {{10.1098/rspb.2010.1071}},
volume = {{277}},
year = {{2010}},
}