Clinically relevant contact allergy to formaldehyde may be missed by testing with formaldehyde 1.0%.
(2011) In British Journal of Dermatology 164(3). p.568-572- Abstract
- Background: It has been found that patch testing with 15μl formaldehyde 2.0% aq detects twice more allergies than testing with 1.0%. The clinical relevance of positive patch test reactions is often difficult to determine. Use tests are simple to do and help to evaluate the significance of patch test results. Objectives: To study the clinical relevance of contact allergy to formaldehyde detected by 2.0% (0.60 mg/cm²) but not by 1.0%. Patients/Methods: 18 patients positive to formaldehyde 2.0% but negative to 1.0% and a control group of 19 dermatitis patients without allergy to parabens, formaldehyde and formaldehyde releasers were included in the study. Formaldehyde 2000 ppm, the maximum concentration permitted in leave-on cosmetics... (More)
- Background: It has been found that patch testing with 15μl formaldehyde 2.0% aq detects twice more allergies than testing with 1.0%. The clinical relevance of positive patch test reactions is often difficult to determine. Use tests are simple to do and help to evaluate the significance of patch test results. Objectives: To study the clinical relevance of contact allergy to formaldehyde detected by 2.0% (0.60 mg/cm²) but not by 1.0%. Patients/Methods: 18 patients positive to formaldehyde 2.0% but negative to 1.0% and a control group of 19 dermatitis patients without allergy to parabens, formaldehyde and formaldehyde releasers were included in the study. Formaldehyde 2000 ppm, the maximum concentration permitted in leave-on cosmetics according to the EU Cosmetics Directive, was added to a batch of a moisturiser preserved with parabens. The same batch without formaldehyde served as control. The study was double-blinded and randomised. The patients were provided with both moisturisers and instructed to apply one of them twice a day on a marked-out 5×5 cm area on the inside of one upper arm and the other moisturiser on the other arm. Reading of the test sites was done once a week for a maximum of 4 weeks. Results: In the control group there were no allergic reactions to any of the moisturisers. 9 of the 17 formaldehyde-allergic patients reacted with an allergic reaction to the moisturiser which contained formaldehyde (p<0.001). No positive reactions were observed to the moisturiser without formaldehyde. Conclusions: Our results demonstrate that contact allergy to formaldehyde 2.0% may be clinically relevant. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1757038
- author
- Dubnika Hauksson, Inese LU ; Pontén, Ann LU ; Gruvberger, Birgitta LU ; Isaksson, Marléne LU and Bruze, Magnus LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Dermatology
- volume
- 164
- issue
- 3
- pages
- 568 - 572
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000288076200018
- pmid:21114477
- scopus:79952396944
- pmid:21114477
- ISSN
- 1365-2133
- DOI
- 10.1111/j.1365-2133.2010.10151.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Occupational and Environmental Dermatology Unit (013241310), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 00684d9e-86ac-470e-a243-ca57c23f74c3 (old id 1757038)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21114477?dopt=Abstract
- date added to LUP
- 2016-04-01 10:20:26
- date last changed
- 2022-04-12 05:21:10
@article{00684d9e-86ac-470e-a243-ca57c23f74c3,
abstract = {{Background: It has been found that patch testing with 15μl formaldehyde 2.0% aq detects twice more allergies than testing with 1.0%. The clinical relevance of positive patch test reactions is often difficult to determine. Use tests are simple to do and help to evaluate the significance of patch test results. Objectives: To study the clinical relevance of contact allergy to formaldehyde detected by 2.0% (0.60 mg/cm²) but not by 1.0%. Patients/Methods: 18 patients positive to formaldehyde 2.0% but negative to 1.0% and a control group of 19 dermatitis patients without allergy to parabens, formaldehyde and formaldehyde releasers were included in the study. Formaldehyde 2000 ppm, the maximum concentration permitted in leave-on cosmetics according to the EU Cosmetics Directive, was added to a batch of a moisturiser preserved with parabens. The same batch without formaldehyde served as control. The study was double-blinded and randomised. The patients were provided with both moisturisers and instructed to apply one of them twice a day on a marked-out 5×5 cm area on the inside of one upper arm and the other moisturiser on the other arm. Reading of the test sites was done once a week for a maximum of 4 weeks. Results: In the control group there were no allergic reactions to any of the moisturisers. 9 of the 17 formaldehyde-allergic patients reacted with an allergic reaction to the moisturiser which contained formaldehyde (p<0.001). No positive reactions were observed to the moisturiser without formaldehyde. Conclusions: Our results demonstrate that contact allergy to formaldehyde 2.0% may be clinically relevant.}},
author = {{Dubnika Hauksson, Inese and Pontén, Ann and Gruvberger, Birgitta and Isaksson, Marléne and Bruze, Magnus}},
issn = {{1365-2133}},
language = {{eng}},
number = {{3}},
pages = {{568--572}},
publisher = {{Wiley-Blackwell}},
series = {{British Journal of Dermatology}},
title = {{Clinically relevant contact allergy to formaldehyde may be missed by testing with formaldehyde 1.0%.}},
url = {{http://dx.doi.org/10.1111/j.1365-2133.2010.10151.x}},
doi = {{10.1111/j.1365-2133.2010.10151.x}},
volume = {{164}},
year = {{2011}},
}