TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia
(2011) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 35(2). p.272-274- Abstract
- TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease... (More)
- TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1790700
- author
- Zainuddin, Norafiza ; Murray, Fiona ; Kanduri, Meena ; Gunnarsson, Rebeqa LU ; Smedby, Karin E. ; Enblad, Gunilla ; Jurlander, Jesper ; Juliusson, Gunnar LU and Rosenquist, Richard
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- TP53 mutation, 17p-deletion, Prognosis, Chronic lymphocytic leukemia
- in
- Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
- volume
- 35
- issue
- 2
- pages
- 272 - 274
- publisher
- Elsevier
- external identifiers
-
- wos:000286460200024
- scopus:78751702338
- pmid:20870288
- ISSN
- 1873-5835
- DOI
- 10.1016/j.leukres.2010.08.023
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)
- id
- 607dac1d-fa58-4df6-a17f-eca7532d14dc (old id 1790700)
- date added to LUP
- 2016-04-01 09:56:48
- date last changed
- 2022-07-21 04:59:36
@article{607dac1d-fa58-4df6-a17f-eca7532d14dc, abstract = {{TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.}}, author = {{Zainuddin, Norafiza and Murray, Fiona and Kanduri, Meena and Gunnarsson, Rebeqa and Smedby, Karin E. and Enblad, Gunilla and Jurlander, Jesper and Juliusson, Gunnar and Rosenquist, Richard}}, issn = {{1873-5835}}, keywords = {{TP53 mutation; 17p-deletion; Prognosis; Chronic lymphocytic leukemia}}, language = {{eng}}, number = {{2}}, pages = {{272--274}}, publisher = {{Elsevier}}, series = {{Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis}}, title = {{TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia}}, url = {{https://lup.lub.lu.se/search/files/1414614/1858243.pdf}}, doi = {{10.1016/j.leukres.2010.08.023}}, volume = {{35}}, year = {{2011}}, }