Anthropometric factors and ovarian cancer risk in the Malmö Diet and Cancer Study.
(2011) In Cancer Epidemiology 35. p.432-437- Abstract
- Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly... (More)
- Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09-0.81; p-trend=0.03) and clinical stages 1 and 2 (RR 0.32; 0.10-0.97; p-trend=0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. Conclusions: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1832339
- author
- Brändstedt, Jenny LU ; Nodin, Björn LU ; Manjer, Jonas LU and Jirström, Karin LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Epidemiology
- volume
- 35
- pages
- 432 - 437
- publisher
- Elsevier
- external identifiers
-
- wos:000296167600007
- pmid:21288792
- scopus:80052916321
- pmid:21288792
- ISSN
- 1877-7821
- DOI
- 10.1016/j.canep.2011.01.003
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery Research Unit (013242220), Pathology (Malmö) (013031000)
- id
- 28f6cb89-c167-4fd0-aa56-67317ae93255 (old id 1832339)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21288792?dopt=Abstract
- date added to LUP
- 2016-04-04 08:36:39
- date last changed
- 2024-01-29 02:53:00
@article{28f6cb89-c167-4fd0-aa56-67317ae93255, abstract = {{Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09-0.81; p-trend=0.03) and clinical stages 1 and 2 (RR 0.32; 0.10-0.97; p-trend=0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. Conclusions: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk.}}, author = {{Brändstedt, Jenny and Nodin, Björn and Manjer, Jonas and Jirström, Karin}}, issn = {{1877-7821}}, language = {{eng}}, pages = {{432--437}}, publisher = {{Elsevier}}, series = {{Cancer Epidemiology}}, title = {{Anthropometric factors and ovarian cancer risk in the Malmö Diet and Cancer Study.}}, url = {{http://dx.doi.org/10.1016/j.canep.2011.01.003}}, doi = {{10.1016/j.canep.2011.01.003}}, volume = {{35}}, year = {{2011}}, }