Troponin I and Creatine Kinase MB do not provide comparable information after PCI
(2011) In Scandinavian Cardiovascular Journal 45(1). p.21-26- Abstract
- Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99<SUth</SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range... (More)
- Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99<SUth</SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range from 1x to 10x99%URL and those with CK-MB 1x to 10x99%URL. Conclusions. With the present quantification scales, infarction rate after PCI is > five-fold higher with cTnI than with CK-MB. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1876913
- author
- Gustavsson, Carl Gunnar LU and Nilson, Margareta
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Angioplasty, CK-MB, creatine kinase, infarction, PCI troponin
- in
- Scandinavian Cardiovascular Journal
- volume
- 45
- issue
- 1
- pages
- 21 - 26
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000286827600003
- scopus:79551528054
- pmid:21114454
- ISSN
- 1651-2006
- DOI
- 10.3109/14017431.2010.536989
- language
- English
- LU publication?
- yes
- id
- e76afd05-361d-41a5-9346-815a14e2dde0 (old id 1876913)
- date added to LUP
- 2016-04-01 13:18:42
- date last changed
- 2022-01-27 18:29:52
@article{e76afd05-361d-41a5-9346-815a14e2dde0, abstract = {{Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99<SUth</SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range from 1x to 10x99%URL and those with CK-MB 1x to 10x99%URL. Conclusions. With the present quantification scales, infarction rate after PCI is > five-fold higher with cTnI than with CK-MB.}}, author = {{Gustavsson, Carl Gunnar and Nilson, Margareta}}, issn = {{1651-2006}}, keywords = {{Angioplasty; CK-MB; creatine kinase; infarction; PCI troponin}}, language = {{eng}}, number = {{1}}, pages = {{21--26}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian Cardiovascular Journal}}, title = {{Troponin I and Creatine Kinase MB do not provide comparable information after PCI}}, url = {{http://dx.doi.org/10.3109/14017431.2010.536989}}, doi = {{10.3109/14017431.2010.536989}}, volume = {{45}}, year = {{2011}}, }