Early Cellular Pathways of Mouse Natural Killer Cell Development.
(2011) In Journal of Innate Immunity 3(4). p.329-336- Abstract
- Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell... (More)
- Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell lineages, the early stages of NK cell lineage commitment and development have been less well established and characterized. Here, I review the progress made thus far in dissecting the developmental stages, from HSCs in the bone marrow to the lineage-committed NK cells in mouse. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1883302
- author
- Sitnicka Quinn, Ewa LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Innate Immunity
- volume
- 3
- issue
- 4
- pages
- 329 - 336
- publisher
- Karger
- external identifiers
-
- wos:000292065600002
- pmid:21447931
- scopus:79959645128
- pmid:21447931
- ISSN
- 1662-811X
- DOI
- 10.1159/000323925
- language
- English
- LU publication?
- yes
- id
- 20871f5f-251c-4847-af8a-a45659187f00 (old id 1883302)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21447931?dopt=Abstract
- date added to LUP
- 2016-04-01 10:41:32
- date last changed
- 2022-01-26 01:35:47
@article{20871f5f-251c-4847-af8a-a45659187f00,
abstract = {{Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell lineages, the early stages of NK cell lineage commitment and development have been less well established and characterized. Here, I review the progress made thus far in dissecting the developmental stages, from HSCs in the bone marrow to the lineage-committed NK cells in mouse.}},
author = {{Sitnicka Quinn, Ewa}},
issn = {{1662-811X}},
language = {{eng}},
number = {{4}},
pages = {{329--336}},
publisher = {{Karger}},
series = {{Journal of Innate Immunity}},
title = {{Early Cellular Pathways of Mouse Natural Killer Cell Development.}},
url = {{https://lup.lub.lu.se/search/files/2057571/1891029.pdf}},
doi = {{10.1159/000323925}},
volume = {{3}},
year = {{2011}},
}