The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL
(2011) Meeting on Signalling and Human Disease 39. p.663-668- Abstract
- FKBPs (FK506-binding proteins) have long been recognized as key regulators of the response to immunosuppressant drugs and as co-chaperones of steroid receptor complexes. More recently, evidence has emerged suggesting that this diverse protein family may also represent cancer biomarkers owing to their roles in cancer progression and response to treatment. FKBPL (FKBP-like) is a novel FKBP with roles in GR (glucocorticoid receptor), AR (androgen receptor) and ER (oestrogen receptor) signalling. FKBPL binds Hsp90 (heat-shock protein 90) and modulates translocation, transcriptional activation and phosphorylation of these steroid receptors. It has been proposed as a novel prognostic and predictive biomarker, where high levels predict for... (More)
- FKBPs (FK506-binding proteins) have long been recognized as key regulators of the response to immunosuppressant drugs and as co-chaperones of steroid receptor complexes. More recently, evidence has emerged suggesting that this diverse protein family may also represent cancer biomarkers owing to their roles in cancer progression and response to treatment. FKBPL (FKBP-like) is a novel FKBP with roles in GR (glucocorticoid receptor), AR (androgen receptor) and ER (oestrogen receptor) signalling. FKBPL binds Hsp90 (heat-shock protein 90) and modulates translocation, transcriptional activation and phosphorylation of these steroid receptors. It has been proposed as a novel prognostic and predictive biomarker, where high levels predict for increased recurrence-free survival in breast cancer patients and enhanced sensitivity to endocrine therapy. Since this protein family has roles in a plethora of signalling pathways, its members represent novel prognostic markers and therapeutic targets for cancer diagnosis and treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1964648
- author
- McKeen, Hayley D. ; Brennan, Donal J. ; Hegarty, Shauna ; Lanigan, Fiona ; Jirström, Karin LU ; Byrne, Christopher ; Yakkundi, Anita ; McCarthy, Helen O. ; Gallagher, William M. and Robson, Tracy
- organization
- publishing date
- 2011
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- cancer biomarker, FK506-binding protein (FKBP), FK506-binding, protein-like (FKBPL), glucocorticoid receptor (GR), oestrogen, steroid, receptor
- host publication
- Biochemical Society Transactions
- volume
- 39
- pages
- 663 - 668
- publisher
- Portland Press
- conference name
- Meeting on Signalling and Human Disease
- conference location
- Belfast, Ireland
- conference dates
- 2010-11-25 - 2010-11-26
- external identifiers
-
- wos:000289958200047
- scopus:79953188016
- pmid:21428958
- ISSN
- 0300-5127
- 1470-8752
- DOI
- 10.1042/BST0390663
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology (Malmö) (013031000), Pathology, (Lund) (013030000)
- id
- 9cc963e9-5453-4f88-b360-f939ad7e05dc (old id 1964648)
- alternative location
- http://www.biochemsoctrans.org/bst/039/0663/0390663.pdf
- date added to LUP
- 2016-04-01 09:59:59
- date last changed
- 2024-04-06 22:42:08
@inproceedings{9cc963e9-5453-4f88-b360-f939ad7e05dc, abstract = {{FKBPs (FK506-binding proteins) have long been recognized as key regulators of the response to immunosuppressant drugs and as co-chaperones of steroid receptor complexes. More recently, evidence has emerged suggesting that this diverse protein family may also represent cancer biomarkers owing to their roles in cancer progression and response to treatment. FKBPL (FKBP-like) is a novel FKBP with roles in GR (glucocorticoid receptor), AR (androgen receptor) and ER (oestrogen receptor) signalling. FKBPL binds Hsp90 (heat-shock protein 90) and modulates translocation, transcriptional activation and phosphorylation of these steroid receptors. It has been proposed as a novel prognostic and predictive biomarker, where high levels predict for increased recurrence-free survival in breast cancer patients and enhanced sensitivity to endocrine therapy. Since this protein family has roles in a plethora of signalling pathways, its members represent novel prognostic markers and therapeutic targets for cancer diagnosis and treatment.}}, author = {{McKeen, Hayley D. and Brennan, Donal J. and Hegarty, Shauna and Lanigan, Fiona and Jirström, Karin and Byrne, Christopher and Yakkundi, Anita and McCarthy, Helen O. and Gallagher, William M. and Robson, Tracy}}, booktitle = {{Biochemical Society Transactions}}, issn = {{0300-5127}}, keywords = {{cancer biomarker; FK506-binding protein (FKBP); FK506-binding; protein-like (FKBPL); glucocorticoid receptor (GR); oestrogen; steroid; receptor}}, language = {{eng}}, pages = {{663--668}}, publisher = {{Portland Press}}, title = {{The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL}}, url = {{http://dx.doi.org/10.1042/BST0390663}}, doi = {{10.1042/BST0390663}}, volume = {{39}}, year = {{2011}}, }