Long-term course of Mycobacterium tuberculosis infection in Swedish birth cohorts during the twentieth century.
Winqvist, Niclas LU ; Björk, Jonas LU ; Miörner, Håkan LU and Björkman, Per LU
(2011)
In The International Journal of Tuberculosis and Lung Disease
15(6).
p.736-740
- Abstract
- Abstract
SETTING:
Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.
OBJECTIVE:
To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.
DESIGN:
Time trend analysis on TB incidence using age-cohort modelling.
RESULTS:
The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a... (More) - Abstract
SETTING:
Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.
OBJECTIVE:
To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.
DESIGN:
Time trend analysis on TB incidence using age-cohort modelling.
RESULTS:
The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a level between 9.8% and 10.7%. The reactivation rate of latent TB infection (LTBI) was 2% after 1967, when indigenous transmission had disappeared.
CONCLUSION:
Although approximately 10% of persons with LTBI developed active TB, the majority of cases occurred shortly after infection, and the rates of reactivation declined over time. This indicates extensive spontaneous clearance of LTBI (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1972525
- author
- Winqvist, Niclas
LU
; Björk, Jonas
LU
; Miörner, Håkan
LU
and Björkman, Per
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The International Journal of Tuberculosis and Lung Disease
- volume
- 15
- issue
- 6
- pages
- 736 - 740
- publisher
- International Union against Tuberculosis and Lung Disease
- external identifiers
-
- wos:000293724800006
- pmid:21575291
- scopus:79955855159
- pmid:21575291
- ISSN
- 1815-7920
- DOI
- 10.5588/ijtld.10.0683
- language
- English
- LU publication?
- yes
- id
- c96f2b44-656e-4eae-b5de-aa2d2adc0723 (old id 1972525)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21575291?dopt=Abstract
- date added to LUP
- 2016-04-04 06:58:20
- date last changed
- 2022-02-20 19:47:11
@article{c96f2b44-656e-4eae-b5de-aa2d2adc0723,
abstract = {{Abstract<br/><br>
SETTING:<br/><br>
Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.<br/><br>
<br/><br>
OBJECTIVE:<br/><br>
To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.<br/><br>
<br/><br>
DESIGN:<br/><br>
Time trend analysis on TB incidence using age-cohort modelling.<br/><br>
<br/><br>
RESULTS:<br/><br>
The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a level between 9.8% and 10.7%. The reactivation rate of latent TB infection (LTBI) was 2% after 1967, when indigenous transmission had disappeared.<br/><br>
<br/><br>
CONCLUSION:<br/><br>
Although approximately 10% of persons with LTBI developed active TB, the majority of cases occurred shortly after infection, and the rates of reactivation declined over time. This indicates extensive spontaneous clearance of LTBI}},
author = {{Winqvist, Niclas and Björk, Jonas and Miörner, Håkan and Björkman, Per}},
issn = {{1815-7920}},
language = {{eng}},
number = {{6}},
pages = {{736--740}},
publisher = {{International Union against Tuberculosis and Lung Disease}},
series = {{The International Journal of Tuberculosis and Lung Disease}},
title = {{Long-term course of Mycobacterium tuberculosis infection in Swedish birth cohorts during the twentieth century.}},
url = {{http://dx.doi.org/10.5588/ijtld.10.0683}},
doi = {{10.5588/ijtld.10.0683}},
volume = {{15}},
year = {{2011}},
}