Allogeneic haematopoietic stem-cell transplantation with reduced intensity conditioning for advanced stage Hodgkin's lymphoma in Sweden: high incidence of post transplant lymphoproliferative disorder
(2011) In Bone Marrow Transplantation 46(6). p.870-875- Abstract
- Allogeneic transplantation after reduced intensity conditioning (allo-RIC) is a treatment option for patients with Hodgkin's lymphoma (HL) relapsing after autologous transplantation. In all, 23 adult patients with HL underwent allo-RIC in Sweden between 2000 and 2007. The median number of previous treatment lines was five and 20 patients (87%) were previously autografted. TRM at 100 days and at 1 year was 13 and 22% respectively. Acute GVHD grades II-IV developed in 7 out of 23 patients (30%) and chronic GVHD in 10 out of 20 patients at risk (50%). The OS and EFS at three years was 59 and 27%, respectively. Four patients (17%) developed post transplant lymphoproliferative disease (PTLD) after a median time of 55 days (range 38-95); two of... (More)
- Allogeneic transplantation after reduced intensity conditioning (allo-RIC) is a treatment option for patients with Hodgkin's lymphoma (HL) relapsing after autologous transplantation. In all, 23 adult patients with HL underwent allo-RIC in Sweden between 2000 and 2007. The median number of previous treatment lines was five and 20 patients (87%) were previously autografted. TRM at 100 days and at 1 year was 13 and 22% respectively. Acute GVHD grades II-IV developed in 7 out of 23 patients (30%) and chronic GVHD in 10 out of 20 patients at risk (50%). The OS and EFS at three years was 59 and 27%, respectively. Four patients (17%) developed post transplant lymphoproliferative disease (PTLD) after a median time of 55 days (range 38-95); two of these patients later died. The study confirmed that allo-RIC is feasible, but associated with a substantial relapse rate: only 20% of the patients were still alive 7 years after the transplant. A finding of high incidence of PTLD needs to be confirmed in a larger trial that includes patients with non-HL and CLL. Bone Marrow Transplantation (2011) 46, 870-875; doi: 10.1038/bmt.2010.238; published online 18 October 2010 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1985604
- author
- Johansson, J-E ; Remberger, M. ; Lazarevic, Vladimir LU ; Hallbook, H. ; Wahlin, A. ; Kimby, E. ; Juliusson, Gunnar LU ; Omar, H. and Hagglund, H.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allogeneic, transplantation, Hodgkin's lymphoma, post transplant, lymphoproliferative disorder, reduced intensity conditioning
- in
- Bone Marrow Transplantation
- volume
- 46
- issue
- 6
- pages
- 870 - 875
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000291383100015
- scopus:79958159262
- pmid:20956959
- ISSN
- 1476-5365
- DOI
- 10.1038/bmt.2010.238
- language
- English
- LU publication?
- yes
- id
- dba179b9-4a49-4a73-bdaf-60b64b762470 (old id 1985604)
- date added to LUP
- 2016-04-01 10:51:38
- date last changed
- 2024-03-24 19:51:57
@article{dba179b9-4a49-4a73-bdaf-60b64b762470, abstract = {{Allogeneic transplantation after reduced intensity conditioning (allo-RIC) is a treatment option for patients with Hodgkin's lymphoma (HL) relapsing after autologous transplantation. In all, 23 adult patients with HL underwent allo-RIC in Sweden between 2000 and 2007. The median number of previous treatment lines was five and 20 patients (87%) were previously autografted. TRM at 100 days and at 1 year was 13 and 22% respectively. Acute GVHD grades II-IV developed in 7 out of 23 patients (30%) and chronic GVHD in 10 out of 20 patients at risk (50%). The OS and EFS at three years was 59 and 27%, respectively. Four patients (17%) developed post transplant lymphoproliferative disease (PTLD) after a median time of 55 days (range 38-95); two of these patients later died. The study confirmed that allo-RIC is feasible, but associated with a substantial relapse rate: only 20% of the patients were still alive 7 years after the transplant. A finding of high incidence of PTLD needs to be confirmed in a larger trial that includes patients with non-HL and CLL. Bone Marrow Transplantation (2011) 46, 870-875; doi: 10.1038/bmt.2010.238; published online 18 October 2010}}, author = {{Johansson, J-E and Remberger, M. and Lazarevic, Vladimir and Hallbook, H. and Wahlin, A. and Kimby, E. and Juliusson, Gunnar and Omar, H. and Hagglund, H.}}, issn = {{1476-5365}}, keywords = {{allogeneic; transplantation; Hodgkin's lymphoma; post transplant; lymphoproliferative disorder; reduced intensity conditioning}}, language = {{eng}}, number = {{6}}, pages = {{870--875}}, publisher = {{Nature Publishing Group}}, series = {{Bone Marrow Transplantation}}, title = {{Allogeneic haematopoietic stem-cell transplantation with reduced intensity conditioning for advanced stage Hodgkin's lymphoma in Sweden: high incidence of post transplant lymphoproliferative disorder}}, url = {{http://dx.doi.org/10.1038/bmt.2010.238}}, doi = {{10.1038/bmt.2010.238}}, volume = {{46}}, year = {{2011}}, }