Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Written pretest information and germline BRCA1/2 pathogenic variant testing in unselected breast cancer patients : predictors of testing uptake

Nilsson, Martin P. LU ; Nilsson, Erik D. LU ; Silfverberg, Barbro ; Borg, Åke LU and Loman, Niklas LU (2019) In Genetics in Medicine 21(1). p.89-96
Abstract

Purpose: This study aimed to evaluate predictors of testing uptake among unselected breast cancer patients who were offered germline BRCA1/2 testing in a prospective study. Methods: Pretest information was provided by a standardized invitation letter instead of in-person counseling. Data was abstracted from medical records. Using multivariate logistic regressions, predictors of testing uptake were analyzed. Results: The overall uptake of testing was 67% (539 of 805 patients). Low uptake rates were found for patients aged ≥80 years (33%), and patients born outside of Europe (37%). In adjusted analysis, age ≥80 years (odds ratio [OR] 0.10; P = 0.002), psychiatric disorders (OR 0.46; P = 0.006), occupation requiring at least 3 years of... (More)

Purpose: This study aimed to evaluate predictors of testing uptake among unselected breast cancer patients who were offered germline BRCA1/2 testing in a prospective study. Methods: Pretest information was provided by a standardized invitation letter instead of in-person counseling. Data was abstracted from medical records. Using multivariate logistic regressions, predictors of testing uptake were analyzed. Results: The overall uptake of testing was 67% (539 of 805 patients). Low uptake rates were found for patients aged ≥80 years (33%), and patients born outside of Europe (37%). In adjusted analysis, age ≥80 years (odds ratio [OR] 0.10; P = 0.002), psychiatric disorders (OR 0.46; P = 0.006), occupation requiring at least 3 years of university or college education (OR 2.03; P = 0.003), and breast cancer or ovarian cancer in first-degree or second-degree relatives (OR 1.66; P = 0.02) were independently associated with uptake of BRCA1/2 testing. Somatic comorbidity in patients aged <70 years was associated with lower testing uptake. Conclusion: Testing uptake varies across different subgroups according to patient-related factors that are readily available in the medical records. Knowledge about these factors enables health care professionals to identify patients who are less likely to pursue genetic testing.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genetics in Medicine
volume
21
issue
1
pages
89 - 96
publisher
Nature Publishing Group
external identifiers
  • pmid:29875420
  • scopus:85048081325
ISSN
1098-3600
DOI
10.1038/s41436-018-0021-9
language
English
LU publication?
yes
id
19eba192-8725-4ed5-adfb-221708d871bc
date added to LUP
2018-06-18 16:11:11
date last changed
2024-03-01 21:04:29
@article{19eba192-8725-4ed5-adfb-221708d871bc,
  abstract     = {{<p>Purpose: This study aimed to evaluate predictors of testing uptake among unselected breast cancer patients who were offered germline BRCA1/2 testing in a prospective study. Methods: Pretest information was provided by a standardized invitation letter instead of in-person counseling. Data was abstracted from medical records. Using multivariate logistic regressions, predictors of testing uptake were analyzed. Results: The overall uptake of testing was 67% (539 of 805 patients). Low uptake rates were found for patients aged ≥80 years (33%), and patients born outside of Europe (37%). In adjusted analysis, age ≥80 years (odds ratio [OR] 0.10; P = 0.002), psychiatric disorders (OR 0.46; P = 0.006), occupation requiring at least 3 years of university or college education (OR 2.03; P = 0.003), and breast cancer or ovarian cancer in first-degree or second-degree relatives (OR 1.66; P = 0.02) were independently associated with uptake of BRCA1/2 testing. Somatic comorbidity in patients aged &lt;70 years was associated with lower testing uptake. Conclusion: Testing uptake varies across different subgroups according to patient-related factors that are readily available in the medical records. Knowledge about these factors enables health care professionals to identify patients who are less likely to pursue genetic testing.</p>}},
  author       = {{Nilsson, Martin P. and Nilsson, Erik D. and Silfverberg, Barbro and Borg, Åke and Loman, Niklas}},
  issn         = {{1098-3600}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{89--96}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Genetics in Medicine}},
  title        = {{Written pretest information and germline BRCA1/2 pathogenic variant testing in unselected breast cancer patients : predictors of testing uptake}},
  url          = {{http://dx.doi.org/10.1038/s41436-018-0021-9}},
  doi          = {{10.1038/s41436-018-0021-9}},
  volume       = {{21}},
  year         = {{2019}},
}