Development of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria
(2017) In Carbohydrate Polymers 175. p.87-95- Abstract
- Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 tim) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was... (More)
- Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 tim) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was for the first time successfully encapsulated in the CMC-Cht based particles with acceptable viability count. Overall, the systems developed are highly promising for probiotic encapsulation and potential delivery in the intestinal tract with the purpose of modulating gut microbiota and improving human health. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/19fb4bb8-4ed5-42b2-be56-eb9e27091b84
- author
- Singh, Poonam ; Medronho, Bruno LU ; Miguel, Maria LU ; da Silva, G J ; Alves, Luis and Lindman, Björn LU
- publishing date
- 2017-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Carbohydrate Polymers
- volume
- 175
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85026403113
- ISSN
- 0144-8617
- DOI
- 10.1016/j.carbpol.2017.06.119
- language
- English
- LU publication?
- no
- id
- 19fb4bb8-4ed5-42b2-be56-eb9e27091b84
- date added to LUP
- 2019-01-03 20:00:02
- date last changed
- 2022-04-25 20:12:18
@article{19fb4bb8-4ed5-42b2-be56-eb9e27091b84, abstract = {{Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 tim) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was for the first time successfully encapsulated in the CMC-Cht based particles with acceptable viability count. Overall, the systems developed are highly promising for probiotic encapsulation and potential delivery in the intestinal tract with the purpose of modulating gut microbiota and improving human health.}}, author = {{Singh, Poonam and Medronho, Bruno and Miguel, Maria and da Silva, G J and Alves, Luis and Lindman, Björn}}, issn = {{0144-8617}}, language = {{eng}}, month = {{11}}, pages = {{87--95}}, publisher = {{Elsevier}}, series = {{Carbohydrate Polymers}}, title = {{Development of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria}}, url = {{http://dx.doi.org/10.1016/j.carbpol.2017.06.119}}, doi = {{10.1016/j.carbpol.2017.06.119}}, volume = {{175}}, year = {{2017}}, }