Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice
(2011) In Immunology Letters 138(2). p.122-128- Abstract
- Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor reactive memory T cells, the mean survival time (MST) of grafts in the anti-CD40L/LFA-1/DST group was 49.8 d. Adding anti-CD44/CD70 mAbs to anti-CD40L/LFA-1/DST treatment. The MST was more than 100 d (MST > 100 d). Compared with anti-CD40L/LFA-1/DST group, anti-CD40L/LFA-1/CD44/CD70/DST group notably reduced the expansion of memory T cells, enhanced the proportion of CD4(+)Foxp3(+) regulatory T cells (Tregs) and suppressed donor-specific... (More)
- Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor reactive memory T cells, the mean survival time (MST) of grafts in the anti-CD40L/LFA-1/DST group was 49.8 d. Adding anti-CD44/CD70 mAbs to anti-CD40L/LFA-1/DST treatment. The MST was more than 100 d (MST > 100 d). Compared with anti-CD40L/LFA-1/DST group, anti-CD40L/LFA-1/CD44/CD70/DST group notably reduced the expansion of memory T cells, enhanced the proportion of CD4(+)Foxp3(+) regulatory T cells (Tregs) and suppressed donor-specific responses. Our data suggest that anti-CD40L/LFA--1/CD44/CD70 mAbs and DST can synergistically inhibit accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice. (C) 2011 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2072135
- author
- Shao, Wei ; Chen, Jibing ; Dai, Helong ; Peng, Yuanzheng ; Wang, Feng ; Xia, Junjie ; Thorlacius, Henrik LU ; Zhu, Qi and Qi, Zhongquan
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Accelerated rejection, Memory T cells, DST, Monoclonal antibodies
- in
- Immunology Letters
- volume
- 138
- issue
- 2
- pages
- 122 - 128
- publisher
- Elsevier
- external identifiers
-
- wos:000293315200005
- scopus:79959556567
- ISSN
- 0165-2478
- DOI
- 10.1016/j.imlet.2011.03.009
- language
- English
- LU publication?
- yes
- id
- 6550a154-65fe-4366-8533-3c0a20906fcc (old id 2072135)
- date added to LUP
- 2016-04-01 10:32:00
- date last changed
- 2022-01-26 00:11:13
@article{6550a154-65fe-4366-8533-3c0a20906fcc, abstract = {{Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor reactive memory T cells, the mean survival time (MST) of grafts in the anti-CD40L/LFA-1/DST group was 49.8 d. Adding anti-CD44/CD70 mAbs to anti-CD40L/LFA-1/DST treatment. The MST was more than 100 d (MST > 100 d). Compared with anti-CD40L/LFA-1/DST group, anti-CD40L/LFA-1/CD44/CD70/DST group notably reduced the expansion of memory T cells, enhanced the proportion of CD4(+)Foxp3(+) regulatory T cells (Tregs) and suppressed donor-specific responses. Our data suggest that anti-CD40L/LFA--1/CD44/CD70 mAbs and DST can synergistically inhibit accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice. (C) 2011 Elsevier B.V. All rights reserved.}}, author = {{Shao, Wei and Chen, Jibing and Dai, Helong and Peng, Yuanzheng and Wang, Feng and Xia, Junjie and Thorlacius, Henrik and Zhu, Qi and Qi, Zhongquan}}, issn = {{0165-2478}}, keywords = {{Accelerated rejection; Memory T cells; DST; Monoclonal antibodies}}, language = {{eng}}, number = {{2}}, pages = {{122--128}}, publisher = {{Elsevier}}, series = {{Immunology Letters}}, title = {{Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice}}, url = {{http://dx.doi.org/10.1016/j.imlet.2011.03.009}}, doi = {{10.1016/j.imlet.2011.03.009}}, volume = {{138}}, year = {{2011}}, }