Multiple Loci in the HLA Complex Are Associated with Addison's Disease.
(2011) In The Journal of clinical endocrinology and metabolism 96. p.1703-1708- Abstract
- Context: A strong association between autoimmune Addison's disease (AAD) and major histocompatibility complex class II-encoded HLA-DRB1-DQA1-DQB1 haplotypes is well known. Recent evidence from other autoimmune diseases has suggested that class I-encoded HLA-A and HLA-B gene variants confer HLA-DRB1-DQA1-DQB1-independent effects on disease. Objective: We aimed to explore AAD predisposing effects of HLA-A and -B and further investigate the role of MICA and HLA-DRB1-DQA1-DQB1 in a much larger material than has previously been studied. Design: HLA-A, -B, -DRB1, and -DQB1 and a microsatellite in MICA were genotyped in 414 AAD patients and 684 controls of Norwegian origin. Results: The strongest association was observed for the DRB1 locus, in... (More)
- Context: A strong association between autoimmune Addison's disease (AAD) and major histocompatibility complex class II-encoded HLA-DRB1-DQA1-DQB1 haplotypes is well known. Recent evidence from other autoimmune diseases has suggested that class I-encoded HLA-A and HLA-B gene variants confer HLA-DRB1-DQA1-DQB1-independent effects on disease. Objective: We aimed to explore AAD predisposing effects of HLA-A and -B and further investigate the role of MICA and HLA-DRB1-DQA1-DQB1 in a much larger material than has previously been studied. Design: HLA-A, -B, -DRB1, and -DQB1 and a microsatellite in MICA were genotyped in 414 AAD patients and 684 controls of Norwegian origin. Results: The strongest association was observed for the DRB1 locus, in which the DRB1*03:01 and DRB1*04:04 conferred increased risk of AAD, particularly in a heterozygous combination [odds ratio 22.13; 95% confidence interval (11.39-43.98); P = 6 × 10(-20)]. After conditioning on DRB1, association with AAD was still present for HLA-B and MICA, suggesting the presence of additional risk factors. Conclusions: The major histocompatibility complex harbors multiple risk loci for AAD, in which DRB1 appears to represent the main risk factor. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2151424
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 96
- pages
- 1703 - 1708
- publisher
- Oxford University Press
- external identifiers
-
- wos:000295879600022
- pmid:21816777
- scopus:80053470015
- pmid:21816777
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2011-0645
- language
- English
- LU publication?
- yes
- id
- 36ef4a0a-db54-40ed-b6f5-e63d18eabcf9 (old id 2151424)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21816777?dopt=Abstract
- date added to LUP
- 2016-04-04 09:32:39
- date last changed
- 2022-01-29 18:21:46
@article{36ef4a0a-db54-40ed-b6f5-e63d18eabcf9, abstract = {{Context: A strong association between autoimmune Addison's disease (AAD) and major histocompatibility complex class II-encoded HLA-DRB1-DQA1-DQB1 haplotypes is well known. Recent evidence from other autoimmune diseases has suggested that class I-encoded HLA-A and HLA-B gene variants confer HLA-DRB1-DQA1-DQB1-independent effects on disease. Objective: We aimed to explore AAD predisposing effects of HLA-A and -B and further investigate the role of MICA and HLA-DRB1-DQA1-DQB1 in a much larger material than has previously been studied. Design: HLA-A, -B, -DRB1, and -DQB1 and a microsatellite in MICA were genotyped in 414 AAD patients and 684 controls of Norwegian origin. Results: The strongest association was observed for the DRB1 locus, in which the DRB1*03:01 and DRB1*04:04 conferred increased risk of AAD, particularly in a heterozygous combination [odds ratio 22.13; 95% confidence interval (11.39-43.98); P = 6 × 10(-20)]. After conditioning on DRB1, association with AAD was still present for HLA-B and MICA, suggesting the presence of additional risk factors. Conclusions: The major histocompatibility complex harbors multiple risk loci for AAD, in which DRB1 appears to represent the main risk factor.}}, author = {{Skinningsrud, Beate and Lie, Benedicte A and Lavant, Ewa and Carlson, Joyce and Erlich, Henry and Akselsen, Hanne E and Gervin, Kristina and Wolff, Anette B and Erichsen, Martina M and Lövås, Kristian and Husebye, Eystein S and Undlien, Dag E}}, issn = {{1945-7197}}, language = {{eng}}, pages = {{1703--1708}}, publisher = {{Oxford University Press}}, series = {{The Journal of clinical endocrinology and metabolism}}, title = {{Multiple Loci in the HLA Complex Are Associated with Addison's Disease.}}, url = {{http://dx.doi.org/10.1210/jc.2011-0645}}, doi = {{10.1210/jc.2011-0645}}, volume = {{96}}, year = {{2011}}, }