Determinants for malignancy in surgically treated adrenal lesions.
(2012) In Langenbeck's Archives of Surgery 397. p.217-223- Abstract
- PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had... (More)
- PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had radiological signs of malignancy more often (p = 0.001) and the patients were more likely to have a history of malignancy (p = 0.001). There were no differences regarding age, gender, body mass index or mode of detection (incidental vs. clinical) between patients with benign and malignant diagnoses. A unilateral uptake on fluorine-18 deoxyglucose positron emission tomography was more frequent in malignant cases than in benign; however, this association did not reach statistical significance. CONCLUSIONS: Size of adrenal lesion, suspicious radiological findings and history of malignancy were factors associated with malignancy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2168705
- author
- Wright, Lucie ; Nordenström, Erik LU and Almquist, Martin LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langenbeck's Archives of Surgery
- volume
- 397
- pages
- 217 - 223
- publisher
- Springer
- external identifiers
-
- wos:000300493600008
- pmid:21935703
- scopus:84858861954
- pmid:21935703
- ISSN
- 1435-2451
- DOI
- 10.1007/s00423-011-0849-9
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Surgery (Lund) (013009000)
- id
- f8cb93bb-c374-4712-8fa8-a421aaaa6869 (old id 2168705)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21935703?dopt=Abstract
- date added to LUP
- 2016-04-04 09:03:53
- date last changed
- 2022-05-16 22:39:21
@article{f8cb93bb-c374-4712-8fa8-a421aaaa6869, abstract = {{PURPOSE: It is difficult to definitively rule out or establish malignancy pre-operatively in patients with adrenal lesions referred for adrenal surgery. The aim of this study was to identify risk factors for a malignant diagnosis in patients treated with adrenalectomy. METHODS: Consecutive adrenalectomies at the Department of Surgery, Lund University Hospital between 2000 and 2009 were identified. Pre-operative clinical, radiological and biochemical data, as well as details on the operation and histology, were retrieved from patients' medical records. RESULTS: There were 175 adrenal operations in 172 patients (98 female and 77 male). There were 28 malignancies. Malignant tumours were larger than in benign cases (p = 0.003), had radiological signs of malignancy more often (p = 0.001) and the patients were more likely to have a history of malignancy (p = 0.001). There were no differences regarding age, gender, body mass index or mode of detection (incidental vs. clinical) between patients with benign and malignant diagnoses. A unilateral uptake on fluorine-18 deoxyglucose positron emission tomography was more frequent in malignant cases than in benign; however, this association did not reach statistical significance. CONCLUSIONS: Size of adrenal lesion, suspicious radiological findings and history of malignancy were factors associated with malignancy.}}, author = {{Wright, Lucie and Nordenström, Erik and Almquist, Martin}}, issn = {{1435-2451}}, language = {{eng}}, pages = {{217--223}}, publisher = {{Springer}}, series = {{Langenbeck's Archives of Surgery}}, title = {{Determinants for malignancy in surgically treated adrenal lesions.}}, url = {{http://dx.doi.org/10.1007/s00423-011-0849-9}}, doi = {{10.1007/s00423-011-0849-9}}, volume = {{397}}, year = {{2012}}, }