Cell-matrix interactions in muscle disease.
(2012) In Journal of Pathology 226. p.200-218- Abstract
- The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we will introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders will be presented as well as advances toward... (More)
- The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we will introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders will be presented as well as advances toward development of treatment. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2200616
- author
- Carmignac, Virginie LU and Durbeej-Hjalt, Madeleine LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Pathology
- volume
- 226
- pages
- 200 - 218
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000299157600006
- pmid:21989954
- scopus:82755181721
- ISSN
- 0022-3417
- DOI
- 10.1002/path.3020
- language
- English
- LU publication?
- yes
- id
- 5d6aa4d1-8fcf-4831-9773-515b8ae65a3d (old id 2200616)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21989954?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:20
- date last changed
- 2022-04-08 00:39:35
@article{5d6aa4d1-8fcf-4831-9773-515b8ae65a3d, abstract = {{The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we will introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders will be presented as well as advances toward development of treatment. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.}}, author = {{Carmignac, Virginie and Durbeej-Hjalt, Madeleine}}, issn = {{0022-3417}}, language = {{eng}}, pages = {{200--218}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Pathology}}, title = {{Cell-matrix interactions in muscle disease.}}, url = {{http://dx.doi.org/10.1002/path.3020}}, doi = {{10.1002/path.3020}}, volume = {{226}}, year = {{2012}}, }