Optimization of preparative chromatographic separation of multiple rare earth elements.
(2011) In Journal of Chromatography A 1218(51). p.9155-9161- Abstract
- This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a multi-objective Differential Evolution algorithm was used, with weighting based on relative value of the components to find optimal operation points along the Pareto front. The objectives of the Pareto front are weighted productivity and weighted yield with purity as an equality constraint. A prioritizing scheme based on relative values is applied... (More)
- This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a multi-objective Differential Evolution algorithm was used, with weighting based on relative value of the components to find optimal operation points along the Pareto front. The objectives of the Pareto front are weighted productivity and weighted yield with purity as an equality constraint. A prioritizing scheme based on relative values is applied for determining the pooling order. A simple rule of thumb for pooling strategy selection is presented. The multi-objective optimization gives a Pareto front which shows the rule of thumb, as a gap in one of the objective functions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2220807
- author
- Max-Hansen, Mark LU ; Ojala, Frida LU ; Kifle, Dejene ; Borg, Niklas LU and Nilsson, Bernt LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Chromatography A
- volume
- 1218
- issue
- 51
- pages
- 9155 - 9161
- publisher
- Elsevier
- external identifiers
-
- wos:000298530000006
- pmid:22079482
- scopus:82555196722
- pmid:22079482
- ISSN
- 0021-9673
- DOI
- 10.1016/j.chroma.2011.10.062
- language
- English
- LU publication?
- yes
- id
- 5f06162d-3e75-42ef-9042-a7661b6a032b (old id 2220807)
- date added to LUP
- 2016-04-01 14:12:31
- date last changed
- 2023-09-03 10:58:32
@article{5f06162d-3e75-42ef-9042-a7661b6a032b, abstract = {{This work presents a method to optimize multi-product chromatographic systems with multiple objective functions. The system studied is a neodymium, samarium, europium, gadolinium mixture separated in an ion exchange chromatography step. A homogeneous Langmuir Mobile Phase Modified model is calibrated to fit the experiments, and then used to perform the optimization task. For the optimization a multi-objective Differential Evolution algorithm was used, with weighting based on relative value of the components to find optimal operation points along the Pareto front. The objectives of the Pareto front are weighted productivity and weighted yield with purity as an equality constraint. A prioritizing scheme based on relative values is applied for determining the pooling order. A simple rule of thumb for pooling strategy selection is presented. The multi-objective optimization gives a Pareto front which shows the rule of thumb, as a gap in one of the objective functions.}}, author = {{Max-Hansen, Mark and Ojala, Frida and Kifle, Dejene and Borg, Niklas and Nilsson, Bernt}}, issn = {{0021-9673}}, language = {{eng}}, number = {{51}}, pages = {{9155--9161}}, publisher = {{Elsevier}}, series = {{Journal of Chromatography A}}, title = {{Optimization of preparative chromatographic separation of multiple rare earth elements.}}, url = {{http://dx.doi.org/10.1016/j.chroma.2011.10.062}}, doi = {{10.1016/j.chroma.2011.10.062}}, volume = {{1218}}, year = {{2011}}, }