How vitamin A metabolizing dendritic cells are generated in the gut mucosa.
(2012) In Trends in Immunology 33. p.42-48- Abstract
- CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3(+) T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103(+) DCs in the steady state and thus which may contribute to driving... (More)
- CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3(+) T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103(+) DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2220837
- author
- Agace, William LU and Persson, Emma LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Immunology
- volume
- 33
- pages
- 42 - 48
- publisher
- Elsevier
- external identifiers
-
- wos:000299713800006
- pmid:22079120
- scopus:84855337070
- pmid:22079120
- ISSN
- 1471-4981
- DOI
- 10.1016/j.it.2011.10.001
- language
- English
- LU publication?
- yes
- id
- 17e4832c-7454-4049-8012-e611f8d0f7a0 (old id 2220837)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22079120?dopt=Abstract
- date added to LUP
- 2016-04-04 08:16:31
- date last changed
- 2022-02-05 23:43:53
@article{17e4832c-7454-4049-8012-e611f8d0f7a0, abstract = {{CD103(+) dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103(+) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3(+) T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103(+) DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.}}, author = {{Agace, William and Persson, Emma}}, issn = {{1471-4981}}, language = {{eng}}, pages = {{42--48}}, publisher = {{Elsevier}}, series = {{Trends in Immunology}}, title = {{How vitamin A metabolizing dendritic cells are generated in the gut mucosa.}}, url = {{http://dx.doi.org/10.1016/j.it.2011.10.001}}, doi = {{10.1016/j.it.2011.10.001}}, volume = {{33}}, year = {{2012}}, }