Serial single-photon emission computed tomographic and transcranial doppler measurements for evaluation of vasospasm after aneurysmal subarachnoid hemorrhage
(2005) In Neurosurgery 57(2). p.237-248- Abstract
- Objective: To assess the clinical value of serial single photon-emission computed tomographic (SPECT) measurements after aneurysmal subarachnoid hemorrhage (SAH). Methods: Thirty-two patients were studied prospectively during the first 26 days after SAH with repeated SPELT measurements; clinical examinations, and transcranial Doppler recordings. Time trends were analyzed with a general linear model. A final SPECT measurement was performed after 1 year. Results: A mean of 2.6 (range, 1-5) SPECT measurements revealed a significant (P=0.001) quadratic curve consistent with initial hypoperfusion and then with hyperperfusion during the acute stage. SPELT findings were significantly associated with transcranial Doppler recordings (P=0.016) and... (More)
- Objective: To assess the clinical value of serial single photon-emission computed tomographic (SPECT) measurements after aneurysmal subarachnoid hemorrhage (SAH). Methods: Thirty-two patients were studied prospectively during the first 26 days after SAH with repeated SPELT measurements; clinical examinations, and transcranial Doppler recordings. Time trends were analyzed with a general linear model. A final SPECT measurement was performed after 1 year. Results: A mean of 2.6 (range, 1-5) SPECT measurements revealed a significant (P=0.001) quadratic curve consistent with initial hypoperfusion and then with hyperperfusion during the acute stage. SPELT findings were significantly associated with transcranial Doppler recordings (P=0.016) and clinical assessments (P=0.008). Patients fulfilling clinical and transcranial Doppler criteria for vasospasm demonstrated a more pronounced relative hypoperfusionj hyperperfusion time course. A multivariate logistic regression analysis identified SPECT measurements obtained during Days 7 to 14 after the SAH as the only independent predictor (beta=0.042, P=0.02) for impaired perfusion after 1 year. Conclusion: Serial SPECT measurements after aneurysmal SAH demonstrate that regional changes in cerebral perfusion follow a nonlinear time trend, and repeated measurements are necessary. This observation, as well as the low feasibility of SPECT, restricts the clinical value of such measurements. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/224837
- author
- Egge, A ; Sjoholm, H ; Waterloo, K ; Solberg, T ; Ingebrigtsen, T and Romner, Bertil LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hemorrhage, subarachnoid, hemodynamics, single-photon emission computed tomography, vasospasm, transcranial Doppler
- in
- Neurosurgery
- volume
- 57
- issue
- 2
- pages
- 237 - 248
- publisher
- Oxford University Press
- external identifiers
-
- wos:000231111200009
- pmid:16094151
- scopus:23244432516
- ISSN
- 0148-396X
- DOI
- 10.1227/01.NEU.0000166538.60333.D6
- language
- English
- LU publication?
- yes
- id
- fdb7ccd1-d032-418b-8666-cabbfa888506 (old id 224837)
- alternative location
- http://www.neurosurgery-online.com/pt/re/neurosurg/abstract.00006123-200508000-00005.htm;jsessionid=GT2MpV7wjNYWBwFJck9LGGFQxwBq0nqpnB8xX25nj5ThMSpW0vhn!-79285651!181195629!8091!-1
- date added to LUP
- 2016-04-01 16:09:03
- date last changed
- 2022-03-14 22:30:39
@article{fdb7ccd1-d032-418b-8666-cabbfa888506, abstract = {{Objective: To assess the clinical value of serial single photon-emission computed tomographic (SPECT) measurements after aneurysmal subarachnoid hemorrhage (SAH). Methods: Thirty-two patients were studied prospectively during the first 26 days after SAH with repeated SPELT measurements; clinical examinations, and transcranial Doppler recordings. Time trends were analyzed with a general linear model. A final SPECT measurement was performed after 1 year. Results: A mean of 2.6 (range, 1-5) SPECT measurements revealed a significant (P=0.001) quadratic curve consistent with initial hypoperfusion and then with hyperperfusion during the acute stage. SPELT findings were significantly associated with transcranial Doppler recordings (P=0.016) and clinical assessments (P=0.008). Patients fulfilling clinical and transcranial Doppler criteria for vasospasm demonstrated a more pronounced relative hypoperfusionj hyperperfusion time course. A multivariate logistic regression analysis identified SPECT measurements obtained during Days 7 to 14 after the SAH as the only independent predictor (beta=0.042, P=0.02) for impaired perfusion after 1 year. Conclusion: Serial SPECT measurements after aneurysmal SAH demonstrate that regional changes in cerebral perfusion follow a nonlinear time trend, and repeated measurements are necessary. This observation, as well as the low feasibility of SPECT, restricts the clinical value of such measurements.}}, author = {{Egge, A and Sjoholm, H and Waterloo, K and Solberg, T and Ingebrigtsen, T and Romner, Bertil}}, issn = {{0148-396X}}, keywords = {{hemorrhage; subarachnoid; hemodynamics; single-photon emission computed tomography; vasospasm; transcranial Doppler}}, language = {{eng}}, number = {{2}}, pages = {{237--248}}, publisher = {{Oxford University Press}}, series = {{Neurosurgery}}, title = {{Serial single-photon emission computed tomographic and transcranial doppler measurements for evaluation of vasospasm after aneurysmal subarachnoid hemorrhage}}, url = {{http://dx.doi.org/10.1227/01.NEU.0000166538.60333.D6}}, doi = {{10.1227/01.NEU.0000166538.60333.D6}}, volume = {{57}}, year = {{2005}}, }