Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons
(2005) In Environmental Health Perspectives 113(9). p.1172-1177- Abstract
- The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from healthy persons and from persons reporting hypersensitivity to electromagnetic fields (EMFs). We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone... (More)
- The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from healthy persons and from persons reporting hypersensitivity to electromagnetic fields (EMFs). We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone H2AX (gamma-H2AX), which have been shown to colocalize in distinct foci with DNA double-strand breaks (DSBs), using immunofluorescence confocal laser microscopy. We found that MWs from GSM mobile telephones affect chromatin conformation and 53BP1/gamma-H2AX foci similar to heat shock. For the first time, we report here that effects of MWs from mobile telephones on human lymphocytes are dependent on carrier frequency. On average, the same response was observed in lymphocytes from hypersensitive and healthy subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/224998
- author
- Markova, E ; Hillert, L ; Malmgren, Lars LU ; Persson, Bertil R LU and Belyaev, IY
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- stress response, hypersensitivity to electromagnetic fields, DNA double-strand breaks, 53BP1 and gamma-H2AX foci, chromatin
- in
- Environmental Health Perspectives
- volume
- 113
- issue
- 9
- pages
- 1172 - 1177
- publisher
- National Institute of Environmental Health Sciences
- external identifiers
-
- wos:000231677700035
- pmid:16140623
- scopus:25844432196
- ISSN
- 1552-9924
- DOI
- 10.1289/ehp.7561
- language
- English
- LU publication?
- yes
- id
- 52fe5f1f-c83c-4bb4-b92d-e98688f969d0 (old id 224998)
- date added to LUP
- 2016-04-01 15:52:47
- date last changed
- 2022-03-22 06:49:34
@article{52fe5f1f-c83c-4bb4-b92d-e98688f969d0, abstract = {{The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from healthy persons and from persons reporting hypersensitivity to electromagnetic fields (EMFs). We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone H2AX (gamma-H2AX), which have been shown to colocalize in distinct foci with DNA double-strand breaks (DSBs), using immunofluorescence confocal laser microscopy. We found that MWs from GSM mobile telephones affect chromatin conformation and 53BP1/gamma-H2AX foci similar to heat shock. For the first time, we report here that effects of MWs from mobile telephones on human lymphocytes are dependent on carrier frequency. On average, the same response was observed in lymphocytes from hypersensitive and healthy subjects.}}, author = {{Markova, E and Hillert, L and Malmgren, Lars and Persson, Bertil R and Belyaev, IY}}, issn = {{1552-9924}}, keywords = {{stress response; hypersensitivity to electromagnetic fields; DNA double-strand breaks; 53BP1 and gamma-H2AX foci; chromatin}}, language = {{eng}}, number = {{9}}, pages = {{1172--1177}}, publisher = {{National Institute of Environmental Health Sciences}}, series = {{Environmental Health Perspectives}}, title = {{Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons}}, url = {{http://dx.doi.org/10.1289/ehp.7561}}, doi = {{10.1289/ehp.7561}}, volume = {{113}}, year = {{2005}}, }