Laser-induced Fluorescence In Malignant and Normal Tissue of Rats Injected With Benzoporphyrin Derivative
(1993) In Photochemistry and Photobiology 57(6). p.978-983- Abstract
- Laser-induced fluorescence was used to characterize the localization of intravenously administered benzoporphyrin derivative-monoacid (BPD-MA) 3 h postinjection in different rat tissue types, including an induced experimental malignant tumor. A comparison of the fluorescence properties and the demarcation potential between the newer sensitizer BPD-MA and four other substances, hematoporphyrin (HP), polyhematoporphyrin ester (PHE), tetrasulfonated phthalocyanine (TSPc) and the commercially available Photofrin earlier investigated, is included. The fluorescence light was induced with a nitrogen laser, emitting at 337 nm. The fluorescence spectrum in the region 380-750 nm was analyzed by a polychromator equipped with a diode array detector.... (More)
- Laser-induced fluorescence was used to characterize the localization of intravenously administered benzoporphyrin derivative-monoacid (BPD-MA) 3 h postinjection in different rat tissue types, including an induced experimental malignant tumor. A comparison of the fluorescence properties and the demarcation potential between the newer sensitizer BPD-MA and four other substances, hematoporphyrin (HP), polyhematoporphyrin ester (PHE), tetrasulfonated phthalocyanine (TSPc) and the commercially available Photofrin earlier investigated, is included. The fluorescence light was induced with a nitrogen laser, emitting at 337 nm. The fluorescence spectrum in the region 380-750 nm was analyzed by a polychromator equipped with a diode array detector. The demarcation potential between tumor and surrounding tissue in terms of fluorescence signal for the tumor model used was 2:1 for BPD-MA. In comparison with the other drugs, HP shows about the same demarcation potential, whereas Photofrin and PHE exhibit about 3 times better and TSPc about 1.5 times better demarcation. By also employing the endogenous tissue fluorescence signature the contrast was enhanced by a factor of about 2 for each of the five drugs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2257242
- author
- Andersson-Engels, Stefan LU ; Ankerst, J LU ; Johansson, Jonas LU ; Svanberg, Katarina LU and Svanberg, Sune LU
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Photochemistry and Photobiology
- volume
- 57
- issue
- 6
- pages
- 978 - 983
- publisher
- American Society for Photobiology
- external identifiers
-
- scopus:0027621220
- ISSN
- 0031-8655
- DOI
- 10.1111/j.1751-1097.1993.tb02958.x
- language
- English
- LU publication?
- yes
- id
- 7dd16d0a-b1dc-4f63-b659-c9b148385832 (old id 2257242)
- date added to LUP
- 2016-04-04 08:16:43
- date last changed
- 2024-01-12 04:25:26
@article{7dd16d0a-b1dc-4f63-b659-c9b148385832, abstract = {{Laser-induced fluorescence was used to characterize the localization of intravenously administered benzoporphyrin derivative-monoacid (BPD-MA) 3 h postinjection in different rat tissue types, including an induced experimental malignant tumor. A comparison of the fluorescence properties and the demarcation potential between the newer sensitizer BPD-MA and four other substances, hematoporphyrin (HP), polyhematoporphyrin ester (PHE), tetrasulfonated phthalocyanine (TSPc) and the commercially available Photofrin earlier investigated, is included. The fluorescence light was induced with a nitrogen laser, emitting at 337 nm. The fluorescence spectrum in the region 380-750 nm was analyzed by a polychromator equipped with a diode array detector. The demarcation potential between tumor and surrounding tissue in terms of fluorescence signal for the tumor model used was 2:1 for BPD-MA. In comparison with the other drugs, HP shows about the same demarcation potential, whereas Photofrin and PHE exhibit about 3 times better and TSPc about 1.5 times better demarcation. By also employing the endogenous tissue fluorescence signature the contrast was enhanced by a factor of about 2 for each of the five drugs.}}, author = {{Andersson-Engels, Stefan and Ankerst, J and Johansson, Jonas and Svanberg, Katarina and Svanberg, Sune}}, issn = {{0031-8655}}, language = {{eng}}, number = {{6}}, pages = {{978--983}}, publisher = {{American Society for Photobiology}}, series = {{Photochemistry and Photobiology}}, title = {{Laser-induced Fluorescence In Malignant and Normal Tissue of Rats Injected With Benzoporphyrin Derivative}}, url = {{https://lup.lub.lu.se/search/files/5174291/2296998.pdf}}, doi = {{10.1111/j.1751-1097.1993.tb02958.x}}, volume = {{57}}, year = {{1993}}, }