3-Hydroxy fatty acids in saliva as diagnostic markers in chronic periodontitis
(2005) In Journal of Microbiological Methods 62(3). p.285-291- Abstract
- Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA... (More)
- Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA analysis in diagnosing peridontitis were, respectively, 0.92, 1.00, 1.00, and 0.90. The results indicate that 3-OH FA analysis of saliva samples is a useful diagnostic method in chronic periodontitis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/226271
- author
- Ferrando, R ; Szponar, Bogumila LU ; Sanchez, A ; Larsson, Lennart LU and Valero-Guillen, P L
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- gas chronnatography-mass spectrometry, acids, anaerobic gram-negative bacteria/periodontal pathogens, 3-hydroxy fatty, periodontitis/etiology, microbial chemical, inarkers
- in
- Journal of Microbiological Methods
- volume
- 62
- issue
- 3
- pages
- 285 - 291
- publisher
- Elsevier
- external identifiers
-
- pmid:15941605
- wos:000231638500004
- scopus:23744441678
- pmid:15941605
- ISSN
- 1872-8359
- DOI
- 10.1016/j.mimet.2005.04.014
- language
- English
- LU publication?
- yes
- id
- cac91171-dd8c-491b-bbd7-33e906b7d472 (old id 226271)
- date added to LUP
- 2016-04-01 12:17:31
- date last changed
- 2022-01-27 01:34:07
@article{cac91171-dd8c-491b-bbd7-33e906b7d472, abstract = {{Saturated straight- and branched-chain 3-hydroxy fatty acids (3-OH FAs) of 10-18 carbon chain lengths were determined in saliva from 27 individuals with chronic periodontitis and 18 healthy individuals by using gas chromatography-tandem mass spectrometry. Of the 14 different 3-OH FAs detected, 3-OH-C-i17:0 was the most abundant in the periodontitis samples while 3-OH-C-14:0 was the most abundant in the healthy individuals. Considering the relative percentages of 3-OH-C-12:0, 3-OH-C-14:0, 3OH-C-i17:0, and 3-OH-C-17:0, 95.6% of all cases were correctly classified as healthy individuals or periodontitis patients by means of discriminant analysis. The sensitivity, specificity, positive predictive value and negative predictive value of 3-OH FA analysis in diagnosing peridontitis were, respectively, 0.92, 1.00, 1.00, and 0.90. The results indicate that 3-OH FA analysis of saliva samples is a useful diagnostic method in chronic periodontitis.}}, author = {{Ferrando, R and Szponar, Bogumila and Sanchez, A and Larsson, Lennart and Valero-Guillen, P L}}, issn = {{1872-8359}}, keywords = {{gas chronnatography-mass spectrometry; acids; anaerobic gram-negative bacteria/periodontal pathogens; 3-hydroxy fatty; periodontitis/etiology; microbial chemical; inarkers}}, language = {{eng}}, number = {{3}}, pages = {{285--291}}, publisher = {{Elsevier}}, series = {{Journal of Microbiological Methods}}, title = {{3-Hydroxy fatty acids in saliva as diagnostic markers in chronic periodontitis}}, url = {{http://dx.doi.org/10.1016/j.mimet.2005.04.014}}, doi = {{10.1016/j.mimet.2005.04.014}}, volume = {{62}}, year = {{2005}}, }