Calcitonin gene-related peptide in cervicogenic headache
(2005) In Cephalalgia 25(9). p.700-703- Abstract
- Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH patients in relation to headache state. To compare plasma CGRP levels between the peripheral and the cranial circulation. Blood from both external jugular veins and from the antecubital vein was drawn from 11 patients with CEH. Plasma CGRP levels were measured by radioimmunoassay. No difference was found between CGRP levels assessed on days with and... (More)
- Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH patients in relation to headache state. To compare plasma CGRP levels between the peripheral and the cranial circulation. Blood from both external jugular veins and from the antecubital vein was drawn from 11 patients with CEH. Plasma CGRP levels were measured by radioimmunoassay. No difference was found between CGRP levels assessed on days with and without headache. There was no difference beween CGRP levels from the symptomatic and the asymptomatic external jugular vein and the antecubital vein. There is no evidence for an activation of the trigeminovascular system in CEH. In certain cases, clinical differentiation between CEH and migraine without aura is difficult. Plasma CGRP levels might serve as a biological marker to distinguish the two headache entities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/229363
- author
- Frese, A ; Schilgen, M ; Edvinsson, Lars LU ; Frandsen, E and Evers, S
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- trigeminovascular activation, Cervicogenic headache, migraine, calcitonin gene-related peptide
- in
- Cephalalgia
- volume
- 25
- issue
- 9
- pages
- 700 - 703
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000231262300003
- pmid:16109051
- scopus:23944503514
- pmid:16109051
- ISSN
- 0333-1024
- DOI
- 10.1111/j.1468-2982.2004.00940.x
- language
- English
- LU publication?
- yes
- id
- f47df7d6-9945-4e7d-845b-f51e882f7af6 (old id 229363)
- date added to LUP
- 2016-04-01 15:52:16
- date last changed
- 2024-02-26 08:52:01
@article{f47df7d6-9945-4e7d-845b-f51e882f7af6, abstract = {{Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH patients in relation to headache state. To compare plasma CGRP levels between the peripheral and the cranial circulation. Blood from both external jugular veins and from the antecubital vein was drawn from 11 patients with CEH. Plasma CGRP levels were measured by radioimmunoassay. No difference was found between CGRP levels assessed on days with and without headache. There was no difference beween CGRP levels from the symptomatic and the asymptomatic external jugular vein and the antecubital vein. There is no evidence for an activation of the trigeminovascular system in CEH. In certain cases, clinical differentiation between CEH and migraine without aura is difficult. Plasma CGRP levels might serve as a biological marker to distinguish the two headache entities.}}, author = {{Frese, A and Schilgen, M and Edvinsson, Lars and Frandsen, E and Evers, S}}, issn = {{0333-1024}}, keywords = {{trigeminovascular activation; Cervicogenic headache; migraine; calcitonin gene-related peptide}}, language = {{eng}}, number = {{9}}, pages = {{700--703}}, publisher = {{Wiley-Blackwell}}, series = {{Cephalalgia}}, title = {{Calcitonin gene-related peptide in cervicogenic headache}}, url = {{http://dx.doi.org/10.1111/j.1468-2982.2004.00940.x}}, doi = {{10.1111/j.1468-2982.2004.00940.x}}, volume = {{25}}, year = {{2005}}, }