A simplified laminin nomenclature
(2005) In Matrix Biology 24(5). p.326-332- Abstract
- A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin... (More)
- A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of 13 chains is named laminin beta-knob (L beta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha IL4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered. (Less)
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https://lup.lub.lu.se/record/229551
- author
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- laminin-type domains, basement membrane, laminin, nomenclature
- in
- Matrix Biology
- volume
- 24
- issue
- 5
- pages
- 326 - 332
- publisher
- Elsevier
- external identifiers
-
- pmid:15979864
- wos:000231205300002
- scopus:22544480570
- pmid:15979864
- ISSN
- 1569-1802
- DOI
- 10.1016/j.matbio.2005.05.006
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Experimental Medical Science (013210000), Pathology, (Lund) (013030000)
- id
- 8dc9b6d9-39e2-414c-8bee-94c2e8247da0 (old id 229551)
- date added to LUP
- 2016-04-01 17:02:19
- date last changed
- 2022-04-23 01:59:33
@article{8dc9b6d9-39e2-414c-8bee-94c2e8247da0, abstract = {{A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of 13 chains is named laminin beta-knob (L beta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha IL4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.}}, author = {{Aumailley, M and Bruckner-Tuderman, L and Carter, W G and Deutzmann, R and Edgar, D and Ekblom, Peter and Engel, J and Engvall, E and Hohenester, E and Jones, J C R and Kleinman, H K and Marinkovich, M P and Martin, G R and Mayer, U and Meneguzzi, G and Miner, J H and Miyazaki, K and Patarroyo, M and Paulsson, M and Quaranta, V and Sanes, J R and Sasaki, T and Sekiguchi, K and Sorokin, Lydia and Talts, Jan and Tryggvason, K and Uitto, J and Virtanen, I and von der Mark, K and Wewer, U M and Yamada, Y and Yurchenco, P D}}, issn = {{1569-1802}}, keywords = {{laminin-type domains; basement membrane; laminin; nomenclature}}, language = {{eng}}, number = {{5}}, pages = {{326--332}}, publisher = {{Elsevier}}, series = {{Matrix Biology}}, title = {{A simplified laminin nomenclature}}, url = {{http://dx.doi.org/10.1016/j.matbio.2005.05.006}}, doi = {{10.1016/j.matbio.2005.05.006}}, volume = {{24}}, year = {{2005}}, }