Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study
(2011) In Blood 118(24). p.6284-6291- Abstract
- The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditions by use of logistic regression. A personal history of all infections combined was associated with a significantly increased risk of MM (OR = 1.2; 95% CI, 1.1-1.3), and a personal history of all conditions in the categories infections (OR = 1.6; 95%... (More)
- The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditions by use of logistic regression. A personal history of all infections combined was associated with a significantly increased risk of MM (OR = 1.2; 95% CI, 1.1-1.3), and a personal history of all conditions in the categories infections (OR = 1.6; 95% CI, 1.5-1.7), inflammatory conditions (OR = 1.4; 95% CI, 1.2-1.5), and autoimmune diseases (OR = 2.1; 95% CI, 1.9-2.4) was associated with a significantly increased risk of MGUS. Several specific immune-related conditions elevated the risk of MM and/or MGUS. A family history of autoimmune disease was associated with a significantly increased risk of MGUS (OR = 1.1; 95% CI, 1.00-1.2), but not MM. Our findings suggest that immune-related conditions and/or their treatment are of importance in the etiology of MGUS and possibly MM. The association of both personal and family history of autoimmune disease with MGUS indicates the potential for shared susceptibility for these conditions. (Blood. 2011; 118(24): 6284-6291) (Less)
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https://lup.lub.lu.se/record/2295932
- author
- Lindqvist, Ebba K. ; Goldin, Lynn R. ; Landgren, Ola ; Blimark, Cecilie ; Mellqvist, Ulf-Henrik ; Turesson, Ingemar LU ; Wahlin, Anders ; Bjorkholm, Magnus and Kristinsson, Sigurdur Y.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 118
- issue
- 24
- pages
- 6284 - 6291
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000298040100011
- scopus:83455259553
- pmid:21998210
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2011-04-347559
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- dfe7211f-dcc2-4738-8c7e-d3bdf87161f5 (old id 2295932)
- date added to LUP
- 2016-04-01 10:06:05
- date last changed
- 2022-01-25 19:40:13
@article{dfe7211f-dcc2-4738-8c7e-d3bdf87161f5,
abstract = {{The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditions by use of logistic regression. A personal history of all infections combined was associated with a significantly increased risk of MM (OR = 1.2; 95% CI, 1.1-1.3), and a personal history of all conditions in the categories infections (OR = 1.6; 95% CI, 1.5-1.7), inflammatory conditions (OR = 1.4; 95% CI, 1.2-1.5), and autoimmune diseases (OR = 2.1; 95% CI, 1.9-2.4) was associated with a significantly increased risk of MGUS. Several specific immune-related conditions elevated the risk of MM and/or MGUS. A family history of autoimmune disease was associated with a significantly increased risk of MGUS (OR = 1.1; 95% CI, 1.00-1.2), but not MM. Our findings suggest that immune-related conditions and/or their treatment are of importance in the etiology of MGUS and possibly MM. The association of both personal and family history of autoimmune disease with MGUS indicates the potential for shared susceptibility for these conditions. (Blood. 2011; 118(24): 6284-6291)}},
author = {{Lindqvist, Ebba K. and Goldin, Lynn R. and Landgren, Ola and Blimark, Cecilie and Mellqvist, Ulf-Henrik and Turesson, Ingemar and Wahlin, Anders and Bjorkholm, Magnus and Kristinsson, Sigurdur Y.}},
issn = {{1528-0020}},
language = {{eng}},
number = {{24}},
pages = {{6284--6291}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study}},
url = {{http://dx.doi.org/10.1182/blood-2011-04-347559}},
doi = {{10.1182/blood-2011-04-347559}},
volume = {{118}},
year = {{2011}},
}