Can histology solve the riddle of non-functioning electrodes; factors influencing the biocompatibillity of brain machine interfaces.
(2011) 194. p.181-189- Abstract
- Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the
near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far
from optimized. There are several factors that need to be addressed and standardized when improving
the long-term success of an implanted electrode. We have chosen to focus on three key factors when
evaluating the evoked tissue responses after electrode implantation into the brain: implant size,
fixation mode, and evaluation period. Further, we show results from an ultrathin multichannel wire
electrode that has been implanted in the rat cerebral cortex for 1 year.
To improve... (More) - Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the
near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far
from optimized. There are several factors that need to be addressed and standardized when improving
the long-term success of an implanted electrode. We have chosen to focus on three key factors when
evaluating the evoked tissue responses after electrode implantation into the brain: implant size,
fixation mode, and evaluation period. Further, we show results from an ultrathin multichannel wire
electrode that has been implanted in the rat cerebral cortex for 1 year.
To improve biocompatibility of implanted electrodes, we would like to suggest that free-floating, very
small, flexible, and, in time, wireless electrodes would elicit a diminished cell encapsulation. We would
also like to suggest standardized methods for the electrode design, the electrode implantation method,
and the analyses of cell reactions after implantation into the CNS in order to improve the long-term
success of implanted neural interfaces. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2335208
- author
- Eriksson Linsmeier, Cecilia LU ; Thelin, Jonas LU and Danielsen, Nils LU
- organization
- publishing date
- 2011
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- cell morphology, brain, electrode, neural cell, micromotion, cell encapsulation
- host publication
- Progress in Brain Research
- editor
- Schouenborg, Jens ; Danielsen, Nils and Garwicz, Martin
- volume
- 194
- pages
- 181 - 189
- publisher
- Elsevier
- external identifiers
-
- wos:000311038900014
- scopus:80051884223
- pmid:21867803
- ISSN
- 0079-6123
- DOI
- 10.1016/B978-0-444-53815-4.00008-X
- language
- English
- LU publication?
- yes
- id
- 26c9ec89-7416-4e93-b83b-bc6211643d1e (old id 2335208)
- date added to LUP
- 2016-04-01 13:17:55
- date last changed
- 2022-09-27 08:33:30
@inbook{26c9ec89-7416-4e93-b83b-bc6211643d1e,
abstract = {{Neural interfaces hold great promise to become invaluable clinical and diagnostic tools in the<br/><br>
near future. However, the biocompatibility and the long-term stability of the implanted interfaces are far<br/><br>
from optimized. There are several factors that need to be addressed and standardized when improving<br/><br>
the long-term success of an implanted electrode. We have chosen to focus on three key factors when<br/><br>
evaluating the evoked tissue responses after electrode implantation into the brain: implant size,<br/><br>
fixation mode, and evaluation period. Further, we show results from an ultrathin multichannel wire<br/><br>
electrode that has been implanted in the rat cerebral cortex for 1 year.<br/><br>
To improve biocompatibility of implanted electrodes, we would like to suggest that free-floating, very<br/><br>
small, flexible, and, in time, wireless electrodes would elicit a diminished cell encapsulation. We would<br/><br>
also like to suggest standardized methods for the electrode design, the electrode implantation method,<br/><br>
and the analyses of cell reactions after implantation into the CNS in order to improve the long-term<br/><br>
success of implanted neural interfaces.}},
author = {{Eriksson Linsmeier, Cecilia and Thelin, Jonas and Danielsen, Nils}},
booktitle = {{Progress in Brain Research}},
editor = {{Schouenborg, Jens and Danielsen, Nils and Garwicz, Martin}},
issn = {{0079-6123}},
keywords = {{cell morphology; brain; electrode; neural cell; micromotion; cell encapsulation}},
language = {{eng}},
pages = {{181--189}},
publisher = {{Elsevier}},
title = {{Can histology solve the riddle of non-functioning electrodes; factors influencing the biocompatibillity of brain machine interfaces.}},
url = {{http://dx.doi.org/10.1016/B978-0-444-53815-4.00008-X}},
doi = {{10.1016/B978-0-444-53815-4.00008-X}},
volume = {{194}},
year = {{2011}},
}