Proton-Induced X-Ray Emission Analysis - A New Tool in Quantitative Dermatology
(1983) In Scanning Electron Microscopy IV. p.1815-1825- Abstract
- Proton-Induced X-ray emission analysis (PIXE) constitutes a method for trace element analysis characterized by multielemental capability, detection limits in the low ppm-range and size resolution down towards a micrometre. In applications where the sensitivity of the Electron-Induced X-ray Emission (EIXE) analysis is not sufficient and where a spatial resolution not better than a few micrometres is required, the PIXE technique provides a powerful tool. In this paper properties of the PIXE method are demonstrated by quantitative results from three different samples of dermatological interest. Firstly, mercury results from a longitudinal scan of a single hair strand from a mercury poisoned person are shown. With a spatial resolution of one... (More)
- Proton-Induced X-ray emission analysis (PIXE) constitutes a method for trace element analysis characterized by multielemental capability, detection limits in the low ppm-range and size resolution down towards a micrometre. In applications where the sensitivity of the Electron-Induced X-ray Emission (EIXE) analysis is not sufficient and where a spatial resolution not better than a few micrometres is required, the PIXE technique provides a powerful tool. In this paper properties of the PIXE method are demonstrated by quantitative results from three different samples of dermatological interest. Firstly, mercury results from a longitudinal scan of a single hair strand from a mercury poisoned person are shown. With a spatial resolution of one or a few millimetres very fast scans may be performed on hair strands giving information on time and magnitude of intoxication or other exposures, as well as deficiencies. Secondly, results are given from a radial scan with a beam width of 4 micron on hair from a person exposed to high amounts of iron. The calcium, iron and zinc distributions but not the sulphur and potassium distributions show narrow peaks of concentration (less than 4 micron) about 15micron from the surface of the hair. Further investigations have to be performed in order to interpret these data. Thirdly, the depth profiles in skin of some elements were measured with a beam width of 10 micron. The results show significant increases in sulphur, calcium and zinc concentrations and significant decreases in phosphorous and potassium concentrations at the skin surface i.e. in the stratum corneum. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2372001
- author
- Malmqvist, Klas LU ; Carlsson, Lars-Eric ; Akselsson, Roland LU and Forslind, Bo
- organization
- publishing date
- 1983
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- proton microprobe, proton-induced X-ray emission (PIXE), external beam, energy-dispersive, electron microprobe, dermatology, hair, skin, cryosectioning
- in
- Scanning Electron Microscopy
- volume
- IV
- pages
- 1815 - 1825
- publisher
- SEM Inc., AMF O'Hare (Chicago), IL, USA
- external identifiers
-
- scopus:0020972876
- ISSN
- 0586-5581
- language
- English
- LU publication?
- yes
- additional info
- This article was presented at Scanning Electron Microscopy/1983 Meeting in the program Advances in Skin Biology, Dearborn, Michigan, USA, April 17-22, 1983 The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007), Ergonomics and Aerosol Technology (011025002)
- id
- eb173cec-620f-4120-bb14-a5209b94ff29 (old id 2372001)
- date added to LUP
- 2016-04-01 17:06:59
- date last changed
- 2021-01-03 06:13:42
@article{eb173cec-620f-4120-bb14-a5209b94ff29,
abstract = {{Proton-Induced X-ray emission analysis (PIXE) constitutes a method for trace element analysis characterized by multielemental capability, detection limits in the low ppm-range and size resolution down towards a micrometre. In applications where the sensitivity of the Electron-Induced X-ray Emission (EIXE) analysis is not sufficient and where a spatial resolution not better than a few micrometres is required, the PIXE technique provides a powerful tool. In this paper properties of the PIXE method are demonstrated by quantitative results from three different samples of dermatological interest. Firstly, mercury results from a longitudinal scan of a single hair strand from a mercury poisoned person are shown. With a spatial resolution of one or a few millimetres very fast scans may be performed on hair strands giving information on time and magnitude of intoxication or other exposures, as well as deficiencies. Secondly, results are given from a radial scan with a beam width of 4 micron on hair from a person exposed to high amounts of iron. The calcium, iron and zinc distributions but not the sulphur and potassium distributions show narrow peaks of concentration (less than 4 micron) about 15micron from the surface of the hair. Further investigations have to be performed in order to interpret these data. Thirdly, the depth profiles in skin of some elements were measured with a beam width of 10 micron. The results show significant increases in sulphur, calcium and zinc concentrations and significant decreases in phosphorous and potassium concentrations at the skin surface i.e. in the stratum corneum.}},
author = {{Malmqvist, Klas and Carlsson, Lars-Eric and Akselsson, Roland and Forslind, Bo}},
issn = {{0586-5581}},
keywords = {{proton microprobe; proton-induced X-ray emission (PIXE); external beam; energy-dispersive; electron microprobe; dermatology; hair; skin; cryosectioning}},
language = {{eng}},
pages = {{1815--1825}},
publisher = {{SEM Inc., AMF O'Hare (Chicago), IL, USA}},
series = {{Scanning Electron Microscopy}},
title = {{Proton-Induced X-Ray Emission Analysis - A New Tool in Quantitative Dermatology}},
url = {{https://lup.lub.lu.se/search/files/4879299/2372006.pdf}},
volume = {{IV}},
year = {{1983}},
}