Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people
(2005) In Diabetes 54(6). p.1884-1891- Abstract
- Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated common sequence variants in PTPN1 with type 2 diabetes and diabetes-related phenotypes. We sought to replicate the association of common single nucleotide polymorphisms (SNPs) and haplotypes in PTPN1 with type 2 diabetes, fasting plasma glucose, and insulin sensitivity in a large collection of subjects. We assessed linkage disequilibrium, selected... (More)
- Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated common sequence variants in PTPN1 with type 2 diabetes and diabetes-related phenotypes. We sought to replicate the association of common single nucleotide polymorphisms (SNPs) and haplotypes in PTPN1 with type 2 diabetes, fasting plasma glucose, and insulin sensitivity in a large collection of subjects. We assessed linkage disequilibrium, selected tag SNPs, and typed these markers in 3,347 cases of type 2 diabetes and 3,347 control subjects as well as 1,189 siblings discordant for type 2 diabetes. Despite power estimated at > 95% to replicate the previously reported associations, no statistically significant evidence of association was observed between PTPN1 SNPs or common haplotypes with type 2 diabetes or with diabetic phenotypes. (Less)
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https://lup.lub.lu.se/record/238768
- author
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 54
- issue
- 6
- pages
- 1884 - 1891
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000229499600033
- pmid:15919813
- scopus:20044376516
- ISSN
- 1939-327X
- language
- English
- LU publication?
- yes
- id
- 98218017-ea28-4b8e-a9b5-38b646de0516 (old id 238768)
- alternative location
- http://diabetes.diabetesjournals.org/cgi/content/full/54/6/1884
- date added to LUP
- 2016-04-01 15:51:26
- date last changed
- 2024-03-22 08:27:29
@article{98218017-ea28-4b8e-a9b5-38b646de0516,
abstract = {{Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated common sequence variants in PTPN1 with type 2 diabetes and diabetes-related phenotypes. We sought to replicate the association of common single nucleotide polymorphisms (SNPs) and haplotypes in PTPN1 with type 2 diabetes, fasting plasma glucose, and insulin sensitivity in a large collection of subjects. We assessed linkage disequilibrium, selected tag SNPs, and typed these markers in 3,347 cases of type 2 diabetes and 3,347 control subjects as well as 1,189 siblings discordant for type 2 diabetes. Despite power estimated at > 95% to replicate the previously reported associations, no statistically significant evidence of association was observed between PTPN1 SNPs or common haplotypes with type 2 diabetes or with diabetic phenotypes.}},
author = {{Florez, J C and Agapakis, C M and Burtt, N P and Sun, M and Almgren, Peter and Råstam, Lennart and Tuomi, T and Gaudet, D and Hudson, T J and Daly, M J and Ardlie, K G and Hirschhorn, J N and Groop, Leif and Altshuler, B}},
issn = {{1939-327X}},
language = {{eng}},
number = {{6}},
pages = {{1884--1891}},
publisher = {{American Diabetes Association Inc.}},
series = {{Diabetes}},
title = {{Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people}},
url = {{http://diabetes.diabetesjournals.org/cgi/content/full/54/6/1884}},
volume = {{54}},
year = {{2005}},
}