Nonlinear compartmental model of F-18-choline
(2012) In Nuclear Medicine and Biology 39(2). p.261-268- Abstract
- Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood... (More)
- Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood and urinary excretion. The linear model tended to overestimate systematically the activity in the liver and in the kidney compartments in the first 20 min post-administration. A nonlinear process of kinetic saturation was considered, according to the typical Michaelis-Menten kinetics. Therefore nonlinear equations were added to describe the flux of 18F-choline from blood to liver and from blood to kidneys. The nonlinear model showed a tendency for improvement in the description of the activity in liver and kidneys, but not for the urine. Conclusions: The simple linear model presented is not able to properly describe the biokinetics of 18F-choline as measured in prostatic cancer patients. The introduction of nonlinear kinetics, although based on physiologically plausible assumptions, resulted in nonsignificant improvements of the model predictive power. (C) 2012 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2409884
- author
- Tavola, Federico ; Janzen, Tilman ; Giussani, Augusto ; Facchinetti, Danya ; Veronese, Ivan ; Uusijärvi, Helena LU ; Mattsson, Sören LU ; Hoeschen, Christoph and Cantone, Marie Claire
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- F-18-Choline, PET, Nonlinear model, Kinetic saturation, Prostate, carcinoma
- in
- Nuclear Medicine and Biology
- volume
- 39
- issue
- 2
- pages
- 261 - 268
- publisher
- Elsevier
- external identifiers
-
- wos:000300121300010
- scopus:84856328287
- pmid:22136887
- ISSN
- 1872-9614
- DOI
- 10.1016/j.nucmedbio.2011.09.002
- language
- English
- LU publication?
- yes
- id
- 43314d69-74b3-4d4a-b189-e441bc0f8df5 (old id 2409884)
- date added to LUP
- 2016-04-01 10:56:39
- date last changed
- 2022-02-10 07:29:22
@article{43314d69-74b3-4d4a-b189-e441bc0f8df5,
abstract = {{Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood and urinary excretion. The linear model tended to overestimate systematically the activity in the liver and in the kidney compartments in the first 20 min post-administration. A nonlinear process of kinetic saturation was considered, according to the typical Michaelis-Menten kinetics. Therefore nonlinear equations were added to describe the flux of 18F-choline from blood to liver and from blood to kidneys. The nonlinear model showed a tendency for improvement in the description of the activity in liver and kidneys, but not for the urine. Conclusions: The simple linear model presented is not able to properly describe the biokinetics of 18F-choline as measured in prostatic cancer patients. The introduction of nonlinear kinetics, although based on physiologically plausible assumptions, resulted in nonsignificant improvements of the model predictive power. (C) 2012 Elsevier Inc. All rights reserved.}},
author = {{Tavola, Federico and Janzen, Tilman and Giussani, Augusto and Facchinetti, Danya and Veronese, Ivan and Uusijärvi, Helena and Mattsson, Sören and Hoeschen, Christoph and Cantone, Marie Claire}},
issn = {{1872-9614}},
keywords = {{F-18-Choline; PET; Nonlinear model; Kinetic saturation; Prostate; carcinoma}},
language = {{eng}},
number = {{2}},
pages = {{261--268}},
publisher = {{Elsevier}},
series = {{Nuclear Medicine and Biology}},
title = {{Nonlinear compartmental model of F-18-choline}},
url = {{http://dx.doi.org/10.1016/j.nucmedbio.2011.09.002}},
doi = {{10.1016/j.nucmedbio.2011.09.002}},
volume = {{39}},
year = {{2012}},
}