A Population-Based Study of Hepatitis D Virus as Potential Risk Factor for Hepatocellular Carcinoma.
Ji, Jianguang LU
; Sundquist, Kristina
LU
and Sundquist, Jan
LU
(2012)
In Journal of the National Cancer Institute
104(10).
p.790-792
- Abstract
- Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register and Outpatient Registry, we identified 9160 patients with chronic HBV infection between 1997 and 2008, of whom 327 had chronic HDV infection and 323 had acute HDV infection. Standardized incidence ratios (SIRs) were calculated for these patients compared with the general population. The risk of hepatocellular carcinoma was greatly increased in patients with HBV and HDV (SIR = 137.17, 95% confidence interval [CI] = 62.19 to 261.51). The risk of... (More)
- Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register and Outpatient Registry, we identified 9160 patients with chronic HBV infection between 1997 and 2008, of whom 327 had chronic HDV infection and 323 had acute HDV infection. Standardized incidence ratios (SIRs) were calculated for these patients compared with the general population. The risk of hepatocellular carcinoma was greatly increased in patients with HBV and HDV (SIR = 137.17, 95% confidence interval [CI] = 62.19 to 261.51). The risk of hepatocellular carcinoma among patients with HBV and HDV was increased (SIR = 6.11, 95% CI = 2.77 to 11.65) when patients with chronic HBV infection alone were used as the reference population. Similar results were observed for patients with chronic HDV infection (SIR = 99.26, 95% CI = 42.39 to 196.55). Our findings indicate that HDV is a strong risk factor for hepatocellular carcinoma. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2431725
- author
- Ji, Jianguang
LU
; Sundquist, Kristina
LU
and Sundquist, Jan
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the National Cancer Institute
- volume
- 104
- issue
- 10
- pages
- 790 - 792
- publisher
- Oxford University Press
- external identifiers
-
- wos:000304199600012
- pmid:22423008
- scopus:84861325331
- pmid:22423008
- ISSN
- 1460-2105
- DOI
- 10.1093/jnci/djs168
- language
- English
- LU publication?
- yes
- id
- 559f01d7-9a1a-4e7e-b859-1c3606fe3aed (old id 2431725)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22423008?dopt=Abstract
- date added to LUP
- 2016-04-04 09:07:24
- date last changed
- 2022-04-23 19:03:39
@article{559f01d7-9a1a-4e7e-b859-1c3606fe3aed,
abstract = {{Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register and Outpatient Registry, we identified 9160 patients with chronic HBV infection between 1997 and 2008, of whom 327 had chronic HDV infection and 323 had acute HDV infection. Standardized incidence ratios (SIRs) were calculated for these patients compared with the general population. The risk of hepatocellular carcinoma was greatly increased in patients with HBV and HDV (SIR = 137.17, 95% confidence interval [CI] = 62.19 to 261.51). The risk of hepatocellular carcinoma among patients with HBV and HDV was increased (SIR = 6.11, 95% CI = 2.77 to 11.65) when patients with chronic HBV infection alone were used as the reference population. Similar results were observed for patients with chronic HDV infection (SIR = 99.26, 95% CI = 42.39 to 196.55). Our findings indicate that HDV is a strong risk factor for hepatocellular carcinoma.}},
author = {{Ji, Jianguang and Sundquist, Kristina and Sundquist, Jan}},
issn = {{1460-2105}},
language = {{eng}},
number = {{10}},
pages = {{790--792}},
publisher = {{Oxford University Press}},
series = {{Journal of the National Cancer Institute}},
title = {{A Population-Based Study of Hepatitis D Virus as Potential Risk Factor for Hepatocellular Carcinoma.}},
url = {{http://dx.doi.org/10.1093/jnci/djs168}},
doi = {{10.1093/jnci/djs168}},
volume = {{104}},
year = {{2012}},
}