The genome of the sea urchin Strongylocentrotus purpuratus
(2006) In Science (New York, N.Y.) 314(5801). p.941-952- Abstract
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
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https://lup.lub.lu.se/record/252776b0-42db-4717-ab3f-50eb0fe20e0b
- author
- author collaboration
- publishing date
- 2006-11-10
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Calcification, Physiologic, Cell Adhesion Molecules/genetics, Complement Activation/genetics, Computational Biology, Embryonic Development/genetics, Evolution, Molecular, Gene Expression Regulation, Developmental, Genes, Genome, Immunity, Innate/genetics, Immunologic Factors/genetics, Male, Nervous System Physiological Phenomena, Proteins/genetics, Sequence Analysis, DNA, Signal Transduction, Strongylocentrotus purpuratus/embryology, Transcription Factors/genetics
- in
- Science (New York, N.Y.)
- volume
- 314
- issue
- 5801
- pages
- 941 - 952
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- scopus:33750995860
- pmid:17095691
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1133609
- language
- English
- LU publication?
- no
- id
- 252776b0-42db-4717-ab3f-50eb0fe20e0b
- date added to LUP
- 2019-11-10 16:55:14
- date last changed
- 2024-09-19 12:49:33
@article{252776b0-42db-4717-ab3f-50eb0fe20e0b, abstract = {{<p>We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.</p>}}, author = {{Sodergren, Erica and Weinstock, George M and Davidson, Eric H and Cameron, R Andrew and Gibbs, Richard A and Angerer, Robert C and Angerer, Lynne M and Arnone, Maria Ina and Burgess, David R and Burke, Robert D and Coffman, James A and Dean, Michael and Elphick, Maurice R and Ettensohn, Charles A and Foltz, Kathy R and Hamdoun, Amro and Hynes, Richard O and Klein, William H and Marzluff, William and McClay, David R and Morris, Robert L and Mushegian, Arcady and Rast, Jonathan P and Smith, L Courtney and Thorndyke, Michael C and Vacquier, Victor D and Wessel, Gary M and Wray, Greg and Zhang, Lan and Elsik, Christine G and Ermolaeva, Olga and Hlavina, Wratko and Hofmann, Gretchen and Kitts, Paul and Landrum, Melissa J and Mackey, Aaron J and Maglott, Donna and Panopoulou, Georgia and Poustka, Albert J and Pruitt, Kim and Sapojnikov, Victor and Song, Xingzhi and Souvorov, Alexandre and Solovyev, Victor and Wei, Zheng and Whittaker, Charles A and Worley, Kim and Durbin, K James and Jackson, Andrew R and Elhaik, Eran and Wright, Rita}}, issn = {{1095-9203}}, keywords = {{Animals; Calcification, Physiologic; Cell Adhesion Molecules/genetics; Complement Activation/genetics; Computational Biology; Embryonic Development/genetics; Evolution, Molecular; Gene Expression Regulation, Developmental; Genes; Genome; Immunity, Innate/genetics; Immunologic Factors/genetics; Male; Nervous System Physiological Phenomena; Proteins/genetics; Sequence Analysis, DNA; Signal Transduction; Strongylocentrotus purpuratus/embryology; Transcription Factors/genetics}}, language = {{eng}}, month = {{11}}, number = {{5801}}, pages = {{941--952}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science (New York, N.Y.)}}, title = {{The genome of the sea urchin Strongylocentrotus purpuratus}}, url = {{http://dx.doi.org/10.1126/science.1133609}}, doi = {{10.1126/science.1133609}}, volume = {{314}}, year = {{2006}}, }