Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?
(2004) In Mediators of Inflammation 13(4). p.275-283- Abstract
- AIMS: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. Results: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. Conclusions: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and... (More)
- AIMS: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. Results: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. Conclusions: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and higher levels of IL-6 herald a greater risk of relapse. Patients with systemic vasculitis in clinical remission have persistent disease activity, kept under control by inhibitory cytokines. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/261697
- author
- Ohlsson, Sophie LU ; Wieslander, Jörgen LU and Segelmark, Mårten LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- inflammation, autoimmunity, anti-neutrophilic cytoplasmatic autoantibodies, interleukin-10, interleukin-8, vasculitis, interleukin-6
- in
- Mediators of Inflammation
- volume
- 13
- issue
- 4
- pages
- 275 - 283
- publisher
- Hindawi Limited
- external identifiers
-
- wos:000224975100007
- pmid:15545059
- scopus:9644270174
- ISSN
- 0962-9351
- DOI
- 10.1080/09629350400003100
- language
- English
- LU publication?
- yes
- id
- 20ddfd87-5b87-4078-8499-e5f9a0b56505 (old id 261697)
- date added to LUP
- 2016-04-01 11:46:19
- date last changed
- 2022-04-20 21:36:06
@article{20ddfd87-5b87-4078-8499-e5f9a0b56505, abstract = {{AIMS: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. Results: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. Conclusions: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and higher levels of IL-6 herald a greater risk of relapse. Patients with systemic vasculitis in clinical remission have persistent disease activity, kept under control by inhibitory cytokines.}}, author = {{Ohlsson, Sophie and Wieslander, Jörgen and Segelmark, Mårten}}, issn = {{0962-9351}}, keywords = {{inflammation; autoimmunity; anti-neutrophilic cytoplasmatic autoantibodies; interleukin-10; interleukin-8; vasculitis; interleukin-6}}, language = {{eng}}, number = {{4}}, pages = {{275--283}}, publisher = {{Hindawi Limited}}, series = {{Mediators of Inflammation}}, title = {{Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?}}, url = {{http://dx.doi.org/10.1080/09629350400003100}}, doi = {{10.1080/09629350400003100}}, volume = {{13}}, year = {{2004}}, }