Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry
(2004) In Journal of Neuroscience Methods 138(1-2). p.65-72- Abstract
- Implanted radiotelemetry has been used for the measurement of cortical electroencephalogram (EEG), locomotor activity, body temperature and cardiovascular parameters. This technique allows high quality data acquisition from freely moving animals with no complications of externalised apparatus. This paper focuses on the methodology for short and long-term monitoring of epileptiform activity by simultaneous cortical EEG, hippocampal (HC) EEG and electromyogram (EMG) in rats. The circadian rhythm of temperature (CRT) was monitored after surgery to estimate the need for post surgical recovery of animals. Different placements of EMG electrodes were assessed in order to minimise artefacts and increase sensitivity. The occurrence of epileptiform... (More)
- Implanted radiotelemetry has been used for the measurement of cortical electroencephalogram (EEG), locomotor activity, body temperature and cardiovascular parameters. This technique allows high quality data acquisition from freely moving animals with no complications of externalised apparatus. This paper focuses on the methodology for short and long-term monitoring of epileptiform activity by simultaneous cortical EEG, hippocampal (HC) EEG and electromyogram (EMG) in rats. The circadian rhythm of temperature (CRT) was monitored after surgery to estimate the need for post surgical recovery of animals. Different placements of EMG electrodes were assessed in order to minimise artefacts and increase sensitivity. The occurrence of epileptiform ictal and interictal activity following an acute injection of either 40 mg/kg pentylenetetrazole (PTZ) or 13.8 mg/kg kainic acid (KA) was investigated. The occurrence of spontaneous seizures was also monitored 5-8 weeks after administration of KA. The present study demonstrated a sensitive method for monitoring cortical EEG, hippocampal EEG and EMG short and long-term by implantable radiotelemetry in freely moving rats. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/267376
- author
- Bastlund, JF ; Jennum, P ; Mohapel, Paul LU ; Vogel, V and Watson, W P
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pentylenetetrazole, kainate, activity, epileptiform, electromyogram, radiotelemetry, electroencephalogram, cortex, hippocampus
- in
- Journal of Neuroscience Methods
- volume
- 138
- issue
- 1-2
- pages
- 65 - 72
- publisher
- Elsevier
- external identifiers
-
- pmid:15325113
- wos:000223804600009
- scopus:7744222156
- ISSN
- 1872-678X
- DOI
- 10.1016/j.jneumeth.2004.03.004
- language
- English
- LU publication?
- yes
- id
- ddc8d8b3-db73-4c68-8c43-3d3c456ed0f6 (old id 267376)
- date added to LUP
- 2016-04-01 12:09:36
- date last changed
- 2022-01-26 23:36:26
@article{ddc8d8b3-db73-4c68-8c43-3d3c456ed0f6, abstract = {{Implanted radiotelemetry has been used for the measurement of cortical electroencephalogram (EEG), locomotor activity, body temperature and cardiovascular parameters. This technique allows high quality data acquisition from freely moving animals with no complications of externalised apparatus. This paper focuses on the methodology for short and long-term monitoring of epileptiform activity by simultaneous cortical EEG, hippocampal (HC) EEG and electromyogram (EMG) in rats. The circadian rhythm of temperature (CRT) was monitored after surgery to estimate the need for post surgical recovery of animals. Different placements of EMG electrodes were assessed in order to minimise artefacts and increase sensitivity. The occurrence of epileptiform ictal and interictal activity following an acute injection of either 40 mg/kg pentylenetetrazole (PTZ) or 13.8 mg/kg kainic acid (KA) was investigated. The occurrence of spontaneous seizures was also monitored 5-8 weeks after administration of KA. The present study demonstrated a sensitive method for monitoring cortical EEG, hippocampal EEG and EMG short and long-term by implantable radiotelemetry in freely moving rats.}}, author = {{Bastlund, JF and Jennum, P and Mohapel, Paul and Vogel, V and Watson, W P}}, issn = {{1872-678X}}, keywords = {{pentylenetetrazole; kainate; activity; epileptiform; electromyogram; radiotelemetry; electroencephalogram; cortex; hippocampus}}, language = {{eng}}, number = {{1-2}}, pages = {{65--72}}, publisher = {{Elsevier}}, series = {{Journal of Neuroscience Methods}}, title = {{Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry}}, url = {{http://dx.doi.org/10.1016/j.jneumeth.2004.03.004}}, doi = {{10.1016/j.jneumeth.2004.03.004}}, volume = {{138}}, year = {{2004}}, }