Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
(2004) In Science 305(5688). p.1283-1286- Abstract
- Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/270682
- author
- Sun, HM ; Ringdahl, Ulrika LU ; Homeister, JW ; Fay, WP ; Engleberg, NC ; Yang, AY ; Rozek, LS ; Wang, XX ; Sjöbring, Ulf LU and Ginsburg, D
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 305
- issue
- 5688
- pages
- 1283 - 1286
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- wos:000223624600039
- pmid:15333838
- scopus:4344601240
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1101245
- language
- English
- LU publication?
- yes
- id
- 1a18611a-23d2-4503-8471-27d99fe6967e (old id 270682)
- date added to LUP
- 2016-04-01 17:14:07
- date last changed
- 2022-04-23 03:36:22
@article{1a18611a-23d2-4503-8471-27d99fe6967e, abstract = {{Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.}}, author = {{Sun, HM and Ringdahl, Ulrika and Homeister, JW and Fay, WP and Engleberg, NC and Yang, AY and Rozek, LS and Wang, XX and Sjöbring, Ulf and Ginsburg, D}}, issn = {{1095-9203}}, language = {{eng}}, number = {{5688}}, pages = {{1283--1286}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science}}, title = {{Plasminogen is a critical host pathogenicity factor for group A streptococcal infection}}, url = {{http://dx.doi.org/10.1126/science.1101245}}, doi = {{10.1126/science.1101245}}, volume = {{305}}, year = {{2004}}, }