An altered immune response to Epstein-Barr virus in multiple sclerosis - A prospective study
(2004) In Neurology 62(12). p.2277-2282- Abstract
- Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy... (More)
- Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/273747
- author
- Sundstrom, P ; Juto, P ; Wadell, G ; Hallmans, G ; Svenningsson, A ; Nystrom, L ; Dillner, Joakim LU and Forsgren, L
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurology
- volume
- 62
- issue
- 12
- pages
- 2277 - 2282
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000222178600023
- pmid:15210894
- scopus:2942752168
- ISSN
- 1526-632X
- language
- English
- LU publication?
- yes
- id
- 78b9cd75-fd1d-4664-933f-c7cab6879d5b (old id 273747)
- alternative location
- http://www.neurology.org/cgi/content/abstract/62/12/2277
- date added to LUP
- 2016-04-01 15:53:02
- date last changed
- 2022-04-07 01:23:06
@article{78b9cd75-fd1d-4664-933f-c7cab6879d5b, abstract = {{Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.}}, author = {{Sundstrom, P and Juto, P and Wadell, G and Hallmans, G and Svenningsson, A and Nystrom, L and Dillner, Joakim and Forsgren, L}}, issn = {{1526-632X}}, language = {{eng}}, number = {{12}}, pages = {{2277--2282}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Neurology}}, title = {{An altered immune response to Epstein-Barr virus in multiple sclerosis - A prospective study}}, url = {{http://www.neurology.org/cgi/content/abstract/62/12/2277}}, volume = {{62}}, year = {{2004}}, }