Vascular endothelial growth factor gene polymorphisms and pre-eclampsia
(2004) In Molecular Human Reproduction 10(5). p.321-324- Abstract
- Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between... (More)
- Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/276170
- author
- Papazoglou, D ; Galazios, G ; Koukourakis, MI ; Panagopoulos, Ioannis LU ; Kontomanolis, EN ; Papatheodorou, K and Maltezos, E
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- vascular endothelial growth factor, pre-eclampsia, polymorphisms
- in
- Molecular Human Reproduction
- volume
- 10
- issue
- 5
- pages
- 321 - 324
- publisher
- Oxford University Press
- external identifiers
-
- pmid:14997002
- wos:000221821100004
- scopus:2642542363
- pmid:14997002
- ISSN
- 1460-2407
- DOI
- 10.1093/molehr/gah048
- language
- English
- LU publication?
- yes
- id
- d37c1511-2257-4e40-a09e-8b61a40cf93e (old id 276170)
- date added to LUP
- 2016-04-01 12:16:42
- date last changed
- 2022-01-27 01:23:04
@article{d37c1511-2257-4e40-a09e-8b61a40cf93e, abstract = {{Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification.}}, author = {{Papazoglou, D and Galazios, G and Koukourakis, MI and Panagopoulos, Ioannis and Kontomanolis, EN and Papatheodorou, K and Maltezos, E}}, issn = {{1460-2407}}, keywords = {{vascular endothelial growth factor; pre-eclampsia; polymorphisms}}, language = {{eng}}, number = {{5}}, pages = {{321--324}}, publisher = {{Oxford University Press}}, series = {{Molecular Human Reproduction}}, title = {{Vascular endothelial growth factor gene polymorphisms and pre-eclampsia}}, url = {{http://dx.doi.org/10.1093/molehr/gah048}}, doi = {{10.1093/molehr/gah048}}, volume = {{10}}, year = {{2004}}, }