Negative neurofilament light and tau immunostaining in frontotemporal dementia
(2004) Frontotemporal Dementias. 4th International Conference 17(4). p.346-349- Abstract
- We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with 6 patients with Alzheimer's disease (AD), and 6 normal controls. In the FTD group, the neuropathological diagnosis was pure frontal-lobe degeneration of non-Alzheimer type (FLD) in 6 cases and in the remaining 2 cases mixed FLD-AD and frontal AD, respectively. The staining for tau was negative in 5 of the FLD cases and faintly positive in 1, but positive in all AD cases. The antibodies against NFM and NFH stained positive in FLD, AD, and controls, whereas the staining for NFL was negative... (More)
- We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with 6 patients with Alzheimer's disease (AD), and 6 normal controls. In the FTD group, the neuropathological diagnosis was pure frontal-lobe degeneration of non-Alzheimer type (FLD) in 6 cases and in the remaining 2 cases mixed FLD-AD and frontal AD, respectively. The staining for tau was negative in 5 of the FLD cases and faintly positive in 1, but positive in all AD cases. The antibodies against NFM and NFH stained positive in FLD, AD, and controls, whereas the staining for NFL was negative in all FLD cases and positive in 1 AD case and in the controls. These findings regarding NFL and tau staining may be useful in the differential diagnosis of FLD and AD. Copyright (C) 2004 S. Karger AG, Basel. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/276686
- author
- Sjogren, M and Englund, Elisabet LU
- organization
- publishing date
- 2004
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Alzheimer's disease, frontotemporal dementia, immunohistochemical, staining, neurofilament light protein, tau protein
- host publication
- Frontotemporal Dementias 4th International Conference (Dementia and Geriatric Cognitive Disorders)
- volume
- 17
- issue
- 4
- pages
- 346 - 349
- publisher
- Karger
- conference name
- Frontotemporal Dementias. 4th International Conference
- conference location
- Lund, Sweden
- conference dates
- 2003-04-24 - 2003-04-26
- external identifiers
-
- wos:000221793000023
- scopus:2642537533
- ISSN
- 1421-9824
- 1420-8008
- DOI
- 10.1159/000077169
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- c380d584-a1e7-4f8e-b3aa-041a1052b343 (old id 276686)
- date added to LUP
- 2016-04-01 11:56:32
- date last changed
- 2024-01-08 02:15:39
@inproceedings{c380d584-a1e7-4f8e-b3aa-041a1052b343, abstract = {{We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with 6 patients with Alzheimer's disease (AD), and 6 normal controls. In the FTD group, the neuropathological diagnosis was pure frontal-lobe degeneration of non-Alzheimer type (FLD) in 6 cases and in the remaining 2 cases mixed FLD-AD and frontal AD, respectively. The staining for tau was negative in 5 of the FLD cases and faintly positive in 1, but positive in all AD cases. The antibodies against NFM and NFH stained positive in FLD, AD, and controls, whereas the staining for NFL was negative in all FLD cases and positive in 1 AD case and in the controls. These findings regarding NFL and tau staining may be useful in the differential diagnosis of FLD and AD. Copyright (C) 2004 S. Karger AG, Basel.}}, author = {{Sjogren, M and Englund, Elisabet}}, booktitle = {{Frontotemporal Dementias 4th International Conference (Dementia and Geriatric Cognitive Disorders)}}, issn = {{1421-9824}}, keywords = {{Alzheimer's disease; frontotemporal dementia; immunohistochemical; staining; neurofilament light protein; tau protein}}, language = {{eng}}, number = {{4}}, pages = {{346--349}}, publisher = {{Karger}}, title = {{Negative neurofilament light and tau immunostaining in frontotemporal dementia}}, url = {{http://dx.doi.org/10.1159/000077169}}, doi = {{10.1159/000077169}}, volume = {{17}}, year = {{2004}}, }