Heme A biosynthesis
(2012) In Biochimica et Biophysica Acta - Bioenergetics 1817(6). p.920-927- Abstract
- Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a... (More)
- Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2799645
- author
- Hederstedt, Lars LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cytochrome biogenesis, Heme synthesis, CtaA, COX15, Oxidase assembly
- in
- Biochimica et Biophysica Acta - Bioenergetics
- volume
- 1817
- issue
- 6
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- wos:000304504200008
- scopus:84860663812
- pmid:22484221
- ISSN
- 0005-2728
- DOI
- 10.1016/j.bbabio.2012.03.025
- language
- English
- LU publication?
- yes
- id
- e54411c6-170a-4a16-a24d-1325f7dcba6f (old id 2799645)
- date added to LUP
- 2016-04-01 14:17:55
- date last changed
- 2022-01-27 23:51:03
@article{e54411c6-170a-4a16-a24d-1325f7dcba6f,
abstract = {{Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved.}},
author = {{Hederstedt, Lars}},
issn = {{0005-2728}},
keywords = {{Cytochrome biogenesis; Heme synthesis; CtaA; COX15; Oxidase assembly}},
language = {{eng}},
number = {{6}},
pages = {{920--927}},
publisher = {{Elsevier}},
series = {{Biochimica et Biophysica Acta - Bioenergetics}},
title = {{Heme A biosynthesis}},
url = {{http://dx.doi.org/10.1016/j.bbabio.2012.03.025}},
doi = {{10.1016/j.bbabio.2012.03.025}},
volume = {{1817}},
year = {{2012}},
}