Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction
(2004) In European Journal of Cardiovascular Prevention & Rehabilitation 11(1). p.33-40- Abstract
- Background The summarized importance of haemostatic and metabolic variables (insulin, lipids including lipoprotein (a) [Lp(a)] and leptin) in predicting first myocardial infarction, as well as possible interactions among these variables, have not been reported. Design A prospective case-control study nested within the Northern Sweden Health and Disease Cohort. Methods Sixty-two men diagnosed with a first myocardial infarction were sex- and age-matched with 124 controls. Conditional logistic regression was conducted including established risk factors, plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) mass concentration, von Willebrand factor, insulin, proinsulin, specific insulin, apolipoprotein... (More)
- Background The summarized importance of haemostatic and metabolic variables (insulin, lipids including lipoprotein (a) [Lp(a)] and leptin) in predicting first myocardial infarction, as well as possible interactions among these variables, have not been reported. Design A prospective case-control study nested within the Northern Sweden Health and Disease Cohort. Methods Sixty-two men diagnosed with a first myocardial infarction were sex- and age-matched with 124 controls. Conditional logistic regression was conducted including established risk factors, plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) mass concentration, von Willebrand factor, insulin, proinsulin, specific insulin, apolipoprotein A-I (apo A-I), Lp(a), and leptin. Interaction analysis was also performed for tPA, apo A-I, Lp(a), leptin and proinsulin. Results Smoking, low plasma levels of apo A-I and high plasma levels of cholesterol, Lp(a), tPA, PAI-1, proinsulin and leptin were associated with myocardial infarction in univariate conditional logistic regression analysis. High tPA [odds ratio (OR), 21.3; 95% confidence interval (CI) 2.04-222] and Lp(a) (OR, 7.21; 95% CI, 1.31-39.8) and low apo A-I (OR, 0.15; 95% CI, 0.02-0.93) remained significant risk determinants in multivariate analysis with smoking habits, body mass index, hypertension, cholesterol, and diabetes included as covariates. There were non-significant synergic interactions between high Lp(a) and leptin and tPA, respectively, and between high Lp(a) and low apo A-I. Conclusion Plasma levels of tPA, Lp(a), and apo A-I are independently associated with subsequent development of a first myocardial infarction in men. (Less)
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https://lup.lub.lu.se/record/284011
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- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- apolipoprotein A-I, lipoprotein(a), leptin, tissue plasminogen activator, myocardial infarction, risk factors
- in
- European Journal of Cardiovascular Prevention & Rehabilitation
- volume
- 11
- issue
- 1
- pages
- 33 - 40
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:15167204
- wos:000220456100005
- scopus:12144291060
- ISSN
- 1741-8275
- DOI
- 10.1097/01.hjr.0000116824.84388.a2
- language
- English
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- yes
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- a82d85dc-a303-42fa-9f55-1c45ab4ac950 (old id 284011)
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- http://www.jcardiovascularrisk.com/pt/re/ejcpr/abstract.00149831-200402000-00006.htm;jsessionid=HhRR9hvbYQNLPphQbNYBz3ZNqpSQY552jRkQpmlpm9pfnYW91dLQ!1071114923!181195629!8091!-1
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@article{a82d85dc-a303-42fa-9f55-1c45ab4ac950,
abstract = {{Background The summarized importance of haemostatic and metabolic variables (insulin, lipids including lipoprotein (a) [Lp(a)] and leptin) in predicting first myocardial infarction, as well as possible interactions among these variables, have not been reported. Design A prospective case-control study nested within the Northern Sweden Health and Disease Cohort. Methods Sixty-two men diagnosed with a first myocardial infarction were sex- and age-matched with 124 controls. Conditional logistic regression was conducted including established risk factors, plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) mass concentration, von Willebrand factor, insulin, proinsulin, specific insulin, apolipoprotein A-I (apo A-I), Lp(a), and leptin. Interaction analysis was also performed for tPA, apo A-I, Lp(a), leptin and proinsulin. Results Smoking, low plasma levels of apo A-I and high plasma levels of cholesterol, Lp(a), tPA, PAI-1, proinsulin and leptin were associated with myocardial infarction in univariate conditional logistic regression analysis. High tPA [odds ratio (OR), 21.3; 95% confidence interval (CI) 2.04-222] and Lp(a) (OR, 7.21; 95% CI, 1.31-39.8) and low apo A-I (OR, 0.15; 95% CI, 0.02-0.93) remained significant risk determinants in multivariate analysis with smoking habits, body mass index, hypertension, cholesterol, and diabetes included as covariates. There were non-significant synergic interactions between high Lp(a) and leptin and tPA, respectively, and between high Lp(a) and low apo A-I. Conclusion Plasma levels of tPA, Lp(a), and apo A-I are independently associated with subsequent development of a first myocardial infarction in men.}},
author = {{Thogersen, AM and Soderberg, S and Jansson, JH and Dahlen, G and Boman, K and Nilsson, TK and Lindahl, B and Weinehall, L and Stenlund, H and Lundberg, V and Johnson, O and Ahrén, Bo and Hallmans, G}},
issn = {{1741-8275}},
keywords = {{apolipoprotein A-I; lipoprotein(a); leptin; tissue plasminogen activator; myocardial infarction; risk factors}},
language = {{eng}},
number = {{1}},
pages = {{33--40}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{European Journal of Cardiovascular Prevention & Rehabilitation}},
title = {{Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction}},
url = {{http://dx.doi.org/10.1097/01.hjr.0000116824.84388.a2}},
doi = {{10.1097/01.hjr.0000116824.84388.a2}},
volume = {{11}},
year = {{2004}},
}