Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation
(2004) In British Journal of Haematology 125(1). p.74-78- Abstract
- Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction... (More)
- Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/284962
- author
- Ekdahl, KN ; Bengtsson, Anders LU ; Andersson, J ; Elgue, G ; Ronnblom, L ; Sturfelt, Gunnar LU and Nilsson, B
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- systemic lupus erythematosus, thrombosis, activation, platelet, beta-thromboglobulin, extracellular phosphorylation
- in
- British Journal of Haematology
- volume
- 125
- issue
- 1
- pages
- 74 - 78
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000220154300011
- pmid:15015972
- scopus:1842557959
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2004.04858.x
- language
- English
- LU publication?
- yes
- id
- 6572e447-b397-457c-8252-b5fefa97a170 (old id 284962)
- date added to LUP
- 2016-04-01 12:16:35
- date last changed
- 2022-09-04 22:36:59
@article{6572e447-b397-457c-8252-b5fefa97a170, abstract = {{Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis.}}, author = {{Ekdahl, KN and Bengtsson, Anders and Andersson, J and Elgue, G and Ronnblom, L and Sturfelt, Gunnar and Nilsson, B}}, issn = {{0007-1048}}, keywords = {{systemic lupus erythematosus; thrombosis; activation; platelet; beta-thromboglobulin; extracellular phosphorylation}}, language = {{eng}}, number = {{1}}, pages = {{74--78}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation}}, url = {{http://dx.doi.org/10.1111/j.1365-2141.2004.04858.x}}, doi = {{10.1111/j.1365-2141.2004.04858.x}}, volume = {{125}}, year = {{2004}}, }