Satellite cells and myonuclei in young and elderly women and men
(2004) In Muscle and Nerve 29(1). p.120-127- Abstract
- The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20-32 years; n = 31) and elderly (age range, 70-83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192-241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had A significantly lower (P < 0.011) number of satellite cells per muscle fiber but a significantly higher (P... (More)
- The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20-32 years; n = 31) and elderly (age range, 70-83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192-241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had A significantly lower (P < 0.011) number of satellite cells per muscle fiber but a significantly higher (P < 0.004) number of myonuclei per muscle fiber. The number of satellite cells relative to the total number of nuclei [satellite cells/(myonuclei + satellite cells)] was significantly lower in the elderly than in the young women and men. These results imply that a reduction in the satellite cell population occurs as a result of increasing age in healthy men and women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/290950
- author
- Kadi, F ; Charifi, N ; Denis, C and Lexell, Jan LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sex characteristics, satellite cells, myonuclei, aging, muscle fibers
- in
- Muscle and Nerve
- volume
- 29
- issue
- 1
- pages
- 120 - 127
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000187747100014
- pmid:14694507
- scopus:0347361625
- ISSN
- 0148-639X
- DOI
- 10.1002/mus.10510
- language
- English
- LU publication?
- yes
- id
- f3fefeb1-c3b7-4689-812f-fa9cf8986277 (old id 290950)
- date added to LUP
- 2016-04-01 12:18:38
- date last changed
- 2022-04-21 05:42:42
@article{f3fefeb1-c3b7-4689-812f-fa9cf8986277,
abstract = {{The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20-32 years; n = 31) and elderly (age range, 70-83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192-241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had A significantly lower (P < 0.011) number of satellite cells per muscle fiber but a significantly higher (P < 0.004) number of myonuclei per muscle fiber. The number of satellite cells relative to the total number of nuclei [satellite cells/(myonuclei + satellite cells)] was significantly lower in the elderly than in the young women and men. These results imply that a reduction in the satellite cell population occurs as a result of increasing age in healthy men and women.}},
author = {{Kadi, F and Charifi, N and Denis, C and Lexell, Jan}},
issn = {{0148-639X}},
keywords = {{sex characteristics; satellite cells; myonuclei; aging; muscle fibers}},
language = {{eng}},
number = {{1}},
pages = {{120--127}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Muscle and Nerve}},
title = {{Satellite cells and myonuclei in young and elderly women and men}},
url = {{http://dx.doi.org/10.1002/mus.10510}},
doi = {{10.1002/mus.10510}},
volume = {{29}},
year = {{2004}},
}